顺铂水溶液降解产物-羟桥双核铂(Ⅱ)化合物的制备和结构  

Preparation and characterization of the hydroxy-bridged dimeric-platinum compound

作　　者：谌喜珠[1] 谢明进[2] 叶青松[1] 刘伟平[1] 余尧[1] 常桥稳[1] 侯树谦[1] 

机构地区：[1]昆明贵金属研究所化学与药物研究室,云南昆明650106 [2]云南大学化学科学与工程学院,云南昆明650091

出　　处：《云南大学学报（自然科学版）》2009年第4期389-392,共4页Journal of Yunnan University(Natural Sciences Edition)

基　　金：国家自然科学基金资助项目(20861004);云南省应用基础基金(重点项目)资助项目(2008CC020)

摘　　要：制备抗癌药顺铂和卡铂在水溶液中的降解产物-羟桥双核铂(Ⅱ)化合物,研究其化学结构.以顺铂为起始原料,通过水合和313 nm紫外光照射,分离出目标化合物.通过测定铂含量,ESI-MS,1H NMR和单晶X衍射分析测定其结构.所得到的化合物为以羟基搭桥的双核铂(Ⅱ)配合物,中心离子与2个氮原子和2个氧原子组成平面正方形,2个中心离子之间的距离为0.309 5 nm,有弱作用.2个配位平面的二面角为2.7°,几乎处于同一平面.2个硝酸根处于配位的外界.To prepare and characterize the hydroxyl- bridged dimeric platinum compound, a degradation product of cisplatin in aqueous solution. The compound was prepared via aquation of cisplatin, followed by irradiation at 313 nm. The chemical structures were characterized by elemental analysis, ESI -MS, ^1H NMR, along with X - ray crystal structure. The compound was determined to be a dimeric platinum （Ⅱ） complex with two hydroxyl groups as its bridged ligand. There are two expected Pt （ Ⅱ） square planes. The angle formed between the planes is 2.7°, suggesting the two planes are actually in the same plane. The length of Pt - Pt is 3. 095 and two nitrate ions lies outside the coordinated sphere.

关 键 词：顺铂 水溶液 降解产物 合成 结构 

分 类 号：O627[理学—有机化学]