祛瘀生新法对药流后大鼠子宫蜕膜孕激素受体PRmRNA及凋亡基因Fas/FaslmRNA表达的影响  

The Effect of Eliminating Blood Stasis to Promote Regeneration of Blood on Rats Pregnancy Decidua PRmRNA and Fas/FaslmRNA that after Medical Abortion

作　　者：于燕[1] 张云竹[2] 王桂媛[1] 周景华[1] 韩凤娟[1] 

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《辽宁中医杂志》2009年第7期1221-1223,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：黑龙江省自然科学基金资助项目(D200649);哈尔滨市科技创新人才研究专项资金资助项目(2006RFQXS106);黑龙江省教育厅科学技术研究资助项目(11521262)

摘　　要：目的:探讨祛瘀生新法的代表方剂生化止血饮对药物流产后大鼠子宫蜕膜PRmRNA及Fas/FaslmRNA表达的影响。方法:40只受孕大鼠随机分为正常孕鼠组、模型组、益母草组、生化止血饮组,采用原位杂交方法检测大鼠子宫蜕膜PRmRNA及Fas/FaslmRNA表达。结果:生化止血饮可降低PRmRNA表达水平,增强Fas/FaslmRNA表达水平,生化止血饮组与模型组及益母草组之间具有显著性差异。结论:祛瘀生新法的代表方剂生化止血饮可明显促进药流后大鼠子宫蜕膜细胞调亡,加快蜕膜脱落,从而达到止血的目的。Objective：To investigate the effect of Shenghua Zhixue Yin from Eliminating blood stasis to promote regeneration of blood on rats pregnancy decidua PRmRNA and Fas/FaslmRNA that after drug-induced abortion. Methods ： Divide 40 rats into normal pregnant group, model group, Yimucao group and Shenghua Zhixue Yin group, detecting the rats pregnancy decidua PRmRNA and Fas/FaslmRNA that after drug - induced abortion in situ hybridization. Resu/ts ： Shenghua Zhixue Yin can reduct PRmRNA and increase Fas/FaslmRNA in pregnancy decidua, between Shenghua Zhixue Yin with model group, Yi mu cao group has Significance difference. Conclusion：Shenghua Zhixue Yin from Eliminating blood stasis to promote regeneration of blood can promote the pregnancy decidua cell apoptosis obviously and accelerate the endometrium regeneration so that stop bleeding quickly.

关 键 词：祛瘀生新 子宫蜕膜 PRmRNA Fas/FaslmRNA 原位杂交 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]