玉女煎对实验性兔牙周炎模型的治疗作用  

Therapeutic Effect of Jade Maid Decoction for Experimental Periodontitis in Rabbits

作　　者：李轶[1] 刘艳辉[1] 王改玲[1] 符路娣[2] 

机构地区：[1]广州中医药大学第一附属医院口腔科,广东广州510405 [2]广州中医药大学实验动物中心,广东广州510405

出　　处：《广州中医药大学学报》2009年第4期367-370,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助项目(编号:2060098);广东省科技厅科技计划项目(编号:2006B35602011)

摘　　要：【目的】观察玉女煎对实验性兔牙周炎模型的治疗作用。【方法】选用新西兰兔24只,随机分为模型对照组、玉女煎组(中药组,剂量为23 g.kg-1.d-1)、局部用药组(以派丽奥牙科软膏每次每牙50 mg局部牙周注射)及中药与局部用药合用组(合用组);采用结扎法复制兔牙周病模型,分别治疗6周,各组均在给药后每周进行牙龈探诊出血(BOP)与牙周探诊深度(PPD)检测,治疗结束后取下颌骨行组织病理学检查。【结果】各治疗组在不同时间点BOP均呈不同程度下降,其中以合用组下降更明显;PPD值亦呈不同程度下降,给药4周后,各治疗组PPD值与模型对照组比较差异均有显著性意义(P<0.05),以合用组疗效更显著。组织病理学检查显示:合用组牙周袋内炎症细胞浸润、骨吸收陷窝及活性破骨细胞数均较其他组减少,且出现牙槽骨再生现象。【结论】中药玉女煎合并局部用药对牙周炎具有一定治疗作用。Objective To observe the therapeutic effect of Jade Maid Decoction （JMD）, a Chinese herbal prescription for nourishing yin and clearing stomach-heat, on experimental periodontitis. Methods Twenty-four New Zealand rabbits were randomized into the model group, JMD group （ oral use of JMD 23 g · kg^-1 · d^-1 ） , external application group （periodontal injection of minoeycline hydrochloride ointment 50mg ）, and the combination group （oral use of JMD and periodontal injection of minocycline hydrochloride ointment ）. Experimental periodontitis was induced by ligation method. The treatment lasted 6 weeks. Gingival bleeding on probing （BOP） and probing pocket depth （PPD） were detected each week after medication, and pathological examination of the mandible was used to confirm the therapeutic effect after treatment. Results Gingival BOP was reduced to various degrees at different time in the three medication groups, and the effect was obvious in the combination group; PPD was also decreased to various degrees, and the difference of PPD between the three medication groups and the model group was significant after treatment for 4 weeks （ P 〈 0. 05 ）, the decrease of PPD being obvious in the combination group. The results of mandibular pathological examination showed that the infiltration of inflammatory cells, bone absorptive lacunae and active osteoclasts were decreased in the combination group as compared with those in the other groups, and alveolar bone regeneration occurred in the combination group. Conclusion JMD combined with periodontal application has certain therapeutic effect for periodontitis.

关 键 词：牙周炎/中西医结合疗法 玉女煎/药理学 牙/病理学 疾病模型 动物 兔 

分 类 号：R285.5[医药卫生—中药学]