胃舒散对五氯硝基苯致肝损伤的保护作用  

Protective Effect of Weishu Powder on Hepatic Injury Induced by Pentachloronitrobenzene

作　　者：林旭楷[1] 张奕鹏[1] 许森源 

机构地区：[1]汕头大学医学院第二附属医院,广东汕头515041 [2]汕头市金石制药总厂,广东汕头515041

出　　处：《广州中医药大学学报》2009年第4期371-373,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省汕头市重点科技计划项目(编号:2007-04)

摘　　要：【目的】观察胃舒散对五氯硝基苯(PCNB)所致肝损伤的保护作用。【方法】SD大鼠随机分为4组,即正常组,模型组,胃舒散高、低剂量组(剂量分别为2.50、1.25 g.kg-1.d-1);除正常组外,其他组均在给药后1 h灌胃PCNB(剂量为400 mg.kg-1.d-1),连续15 d。检测各组肝脏指数,血清谷草转氨酶(GOT)、碱性磷酸酶(ALP)水平和肝组织丙二醛(MDA)含量,并行肝组织病理学检查。【结果】与正常组比较,模型组肝脏指数,血清GOT、ALP水平,肝组织MDA含量均显著升高(P<0.05或P<0.01),肝组织坏死灶数显著增加(P<0.01);胃舒散高、低剂量组可显著降低肝脏指数,血清GOT、ALP水平和肝组织MDA含量,减少肝组织坏死灶数(与模型组比较,P<0.05或P<0.01),减轻肝组织病理损伤。【结论】胃舒散对PCNB所致肝损伤具有一定的保护作用。Objective To observe the protective effect of Weishu Powder （WP） on hepatic injury induced by pentachloronitrobenzene （PCNB）. Methods SD rats were randomized into 4 groups： normal group, model group, high-dosage WP group （ in the dose of 2.50 g·kg^-1·d^-1 ） and low-dosage WP group （ in the dose of 1.25 g·kg^-1·d^-1） . Except the normal group, the other three groups received gastric garage of PCNB 400 mg ·kg^-1·d^-1 for 15 continuous days. After treatment, hepatic index was assayed, serum glutamic-oxalacetic transaminase （GOT） and alkaline phosphatase （ALP） levels and hepatic malondialdehyde （MDA） content were detected, and hepatic pathological examination was also carried out. Results Hepatic index, serum GOT and ALP levels, and hepatic MDA content were increased （ P 〈 0. 05 or P 〈 0. 01 ） , and the number of hepatic necrotic loci was also increased in the model group （P 〈 0. 01 compared with the normal group）. High- and low-dosage WP had counteraction on the above changes （P 〈0.05 or P 〈 0. 01 ）. Conclusion WP exerts certain protective effect on hepatic injury induced by PCNB.

关 键 词：胃舒散/药理学 肝损伤/中药疗法 肝/病理学 疾病模型 动物 大鼠 

分 类 号：R285.5[医药卫生—中药学]