Synthesis,Crystal Structure and Interaction with DNA of a Novel Chromium(Ⅲ) Complex Containing Salicylaldehyde Semicarbazone  

Synthesis,Crystal Structure and Interaction with DNA of a Novel Chromium(Ⅲ) Complex Containing Salicylaldehyde Semicarbazone

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作  者:岳蕾 周荫庄 刘金丽 屠淑洁 肖岭梅 

机构地区:[1]Department of Chemistry Capital Normal University

出  处:《Chinese Journal of Structural Chemistry》2009年第7期789-796,共8页结构化学(英文)

基  金:Supported by the Scientific Research Common Program of Beijing Municipal Commission of Education, PRC (KM200510028005)

摘  要:The novel chromium(Ⅲ) complex with salicylaldehyde semicarbazone was synthesized and characterized by IR spectra and single-crystal X-ray diffraction analysis. The crystal belongs to the orthorhombic system, space group Pbca with a = 8.9849(13), b = 12.0475(16), c = 34.522(5)A, V = 3736.9(9)A3, Z = 8, C16H18C1CrN6O5, Mr= 461.81, De= 1.642 g/cm^3, F(000) = 1896,A(MoKα) = 0.799 mm^-1, the final R = 0.0370 and wR = 0.0827 for 2908 observed reflections with I 〉 2σ(I). The interaction between the chromium(Ⅲ) complex with calf thymus DNA (Ct-DNA) has been investigated by absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. The results indicated that the complex was bonded to Ct-DNA through a non-classical intercalative mode.The novel chromium(Ⅲ) complex with salicylaldehyde semicarbazone was synthesized and characterized by IR spectra and single-crystal X-ray diffraction analysis. The crystal belongs to the orthorhombic system, space group Pbca with a = 8.9849(13), b = 12.0475(16), c = 34.522(5)A, V = 3736.9(9)A3, Z = 8, C16H18C1CrN6O5, Mr= 461.81, De= 1.642 g/cm^3, F(000) = 1896,A(MoKα) = 0.799 mm^-1, the final R = 0.0370 and wR = 0.0827 for 2908 observed reflections with I 〉 2σ(I). The interaction between the chromium(Ⅲ) complex with calf thymus DNA (Ct-DNA) has been investigated by absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. The results indicated that the complex was bonded to Ct-DNA through a non-classical intercalative mode.

关 键 词:chromium(Ⅲ) complex SEMICARBAZONE crystal structure calf thymus DNA 

分 类 号:O627.63[理学—有机化学]

 

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