阿尔茨海默病患者7α-羟化酶基因多态性与血脂关系的研究  

Study on Cholesterol 7α-hydroxylase gene polymorphism and levels of lipids of Alzheimer's disease

作　　者：赵朝贤[1] 吕英刚[2] 周涛[3] 张园[1] 祝春燕[3] 刘春燕[1] 赵晓唐[1] 贾丽霞[1] 高丽萍[4] 

机构地区：[1]河北工程大学医学院,河北邯郸056002 [2]河北工程大学附属医院 [3]邯郸市第一医院 [4]北京联合大学应用文理学院

出　　处：《中国实验诊断学》2009年第7期891-892,共2页Chinese Journal of Laboratory Diagnosis

基　　金：河北省科技攻关项目(06276102D-56)

摘　　要：目的探讨胆固醇7α-羟化酶(cholesterol 7α-hydroxylase,CYP7A1)基因多态性与阿尔茨海默病(AD)的关系。方法用PCR-RFLP方法分析7α-羟化酶A-204C多态性。结果A-204C多态性基因型频率、等位基因A、C频率在组间比较差异无显著性(P>0.05),但基因型为CC的AD患者,其TC和LDL-C水平显著高于基因型为AC的AD患者(P<0.05)。结论7α-羟化酶A-204C多态性与AD无相关性(P>0.05),但患者组CC基因型与TC、LDL-C水平密切相关(P<0.01)。Objective To study the association of cholesterol 7α-hydroxylase （CYP7A1） gene polymorphism with Alzheimer＇ s disease（AD） .Methods cholesterol 7a-hydroxylase genotyping was performed using polymerase chain reaction-restriction fragment polymorphism. Results There was no significant difference in frequencies of allele and genotype in A-204C polymorphism between AD group and control group（ P 〉 0.05）. However, the levels of TC and LDL-C in AD patients with CC genotype was higher than that in AD patients with AC genotype（ P 〈 0.05）. Conclusion No direct association was found between the A-204C polymoiphism and AD,but there is a significant correlation between the CC genotype of the cholesterol 7α-hydroxylase gene and the levels of TC and LDL-C in AD group.

关 键 词：胆固醇7Α-羟化酶 阿尔茨海默病 基因多态性 

分 类 号：R749.16[医药卫生—神经病学与精神病学]