头孢唑肟钠合成工艺研究  

Production technology of ceftizoxime sodium

作　　者：朱小芝 张爱荣 张海燕 白斌艳 

机构地区：[1]山西华元医药集团有限公司,太原030032

出　　处：《山西医科大学学报》2009年第7期617-620,共4页Journal of Shanxi Medical University

摘　　要：目的对头孢唑肟钠的合成工艺条件进行研究。方法以廉价的乙酰乙酸乙酯为起始原料,经亚硝化、溴化、环合、甲基化一锅反应,水解后得氨噻肟酸,与N-羟基邻苯二甲酰亚胺反应合成邻苯二甲酰亚胺氨噻肟活性酯,然后与7-氨基-3-去甲基-3-头孢烷酸(7-ANCA)缩合制得头孢唑肟酸,再与成盐剂反应得头孢唑肟。结果该合成工艺切实可行,其产率达到93.5%。结论该合成工艺操作简单,原料易得,总收率高,副反应少,同时降低了成本,具有良好的应用前景。Objective To study the conditions for production technology of ceflizoxime sodium. Methods Cefotaxime ammonia acid was first prepared from the cheap ethyl acetoacetate to carry out nitrosation, bromination, cyclization, methylation-pot reaction, and hy- drolysis. Then phthalimide ammonia cefotaxime active ester was composed by the reaction with N-hydroxyphthalimide, and then cefti- zoxime acid was obtained by condensation with 7-ANCA. The ceftizoxime sodium was finally obtained by the reaction with salt agent. Results The process was practicable,and the yield was 93.5%. Conclusion The synthetic process is simple, easy to get raw materials with a high total yield, few side effects,low cost, and has a good application prospect.

关 键 词：头孢唑肟钠 合成 乙酰乙酸乙酯 N-羟基邻苯二甲酰亚胺 7-氨基-3-去甲基-3-头孢烷酸 

分 类 号：TQ460.6[化学工程—制药化工]