拟肾上腺素药盐酸甲氧明的绿色合成  

Green synthesis of adrenomimetic drug methoxamine hydrochloride

作　　者：谢宇[1] 胡金刚[1] 魏娅[1] 

机构地区：[1]南昌航空大学环境与化学工程学院,江西南昌330063

出　　处：《现代化工》2009年第7期51-53,共3页Modern Chemical Industry

基　　金：基金项目：江西省自然科学基金项目（0620071）;江西省教育厅科技项目（赣教技字[2007]168号）;航空高校基金（EA200502138）资助项目

摘　　要：采用对苯二酚为原料，依次优化了对羟基的甲基化、傅克酰基化、肟化反应、肟基还原反应、酮胺氢化反应，最终以经济环保的路线合成了目标产物。中间体和目标物经核磁共振氢谱、红外光谱及元素分析仪等确证了其化学结构。与传统盐酸甲氧明工艺相比，采用了绿色合成及简易的提纯工序，五步反应的收率分别为94％、72％、80％、79％及88％。With p-dihydroxybenzene as a raw material, the target product is finally prepared by an economical and environment-friendly synthetic route including optimally five steps of reactions of hydroxide radical methylation, Friedel-Crafts acylation, oximation, oximation reduction and keto-amine hydrogenation in proper order. The structure of the intermediate and target products are confirmed by IH-NMR,IR and elemental analysis, etc. Compared to the traditional process of methoxamine hydrochloride, this process is greener and the purification process is simpler. The yields of the five steps of reactions can be 94%,72% ,80% ,79% and 88% respectively.

关 键 词：甲氧明 甲基化 肟化 还原 绿色合成 

分 类 号：R971.93[医药卫生—药品]