嵌合体在非清髓性造血干细胞移植中的研究进展  

Development of chimerism study in hematopoietic stem cell transplantation

作　　者：马莉(综述)[1] 王列样(综述)[1] 苏丽萍(审校)[1] 

机构地区：[1]山西省肿瘤医院血液科,太原030013

出　　处：《白血病．淋巴瘤》2009年第7期441-443,共3页Journal of Leukemia & Lymphoma

基　　金：基金项目：山西医科大学科技创新项目（01200809）

摘　　要：供者细胞在受者体内的植入情况即嵌合状态与移植物抗宿主病（GVHD）的发生和恶性血液病的复发均密切相关。非清髓性异基因造血干细胞移植术（allo—HSCT）后早期检测供受者嵌合状态是一种简单、至关重要而有效的方法，能够实现早期判断allo—HSCT后疾病的转归，对于提高移植成功率、减少疾病复发、改善患者生活质量有着重要的意义。Hematopoietic chimerism is a measure of the number of donor and recipient cells in the host following hematopoietic stem cell transplantation （HSCT）, and it has a good correlation with GVHD and relapse. Chimerism detection after nonmyeloablative allo-HSCT is a simple essential and effective method to predict the outcome of the disease, and can significantly improve the success rate of transplants, reduce the recurrence and then improve the quanlity of life of patients.

关 键 词：嵌合体 造血干细胞移植 移植免疫学 

分 类 号：R457.7[医药卫生—治疗学] R161[医药卫生—临床医学]