石杉碱甲双层缓释片的研制及体外释药研究  

Preparation of Huperzine A Double-layer Sustained Release Tablets and Their in Vitro Release Characteristics

作　　者：周红祖[1] 刘湘丹[2] 余惠旻[3] 

机构地区：[1]深圳市中医院,深圳市518020 [2]湖南中医药大学药学院,长沙市410208 [3]深圳大学医学院,深圳市518060

出　　处：《中国药房》2009年第21期1628-1630,共3页China Pharmacy

摘　　要：目的：研制石杉碱甲双层缓释片并考察其体外释药特征。方法：缓释层以HPMCK4M为缓释骨架材料，乳糖为稀释剂；速释层以淀粉-碳酸钙为稀释剂，羧甲基淀粉钠为崩解剂，压制双层片，高效液相色谱法检测释放度。结果：制备的石杉碱甲双层片速释层在1--2min崩解，呈粉末状，符合要求；缓释层的释药曲线用Higuchi方程拟合，可维持12h释药。结论：该处方下研制的石杉碱甲双层缓释片可达到既速效又长效的目的。OBJECTIVE： To study the preparation of Huperzine - A double - layer sustained release tablets and their in vitro release characteristics. METHODS： With HPMC K4M as matrix and lactose as diluting agent for the sustained release layer, and with starch - calcium carbonate as diluting agent and sodium carboxymethyl starch as disintegrating agent for the fast release layer to prepare the double- layer tablets by compression, with the release rate of the compressed tablets determined by HPLC. RESULTS： The fast release layer of the prepared Huperzine- A double- layer tablets disintegrated within 1--2 min and appeared as fine powder, meeting the requirement; the release curve of the sustained release layer of the tablets was in line with Higuchi equation and maintained a sustained release of 12 hours. CONCLUSION： The prepared Huperzine- A double- layer tables achieved the goal of both immediate release and sustained release.

关 键 词：石杉碱甲 双层片 均匀设计 体外释药 

分 类 号：R283.64[医药卫生—中药学] R284.2[医药卫生—中医学]