女性系统性红斑狼疮患者血清Th相关细胞因子水平分析  

Analysis of serum threlated cytokine levels in female patients with systemic lupus erythematosus

作　　者：武尚文[1] 

机构地区：[1]山东中医药大学第二附属医院肾内科,250001

出　　处：《中国实用医药》2009年第21期35-37,共3页China Practical Medicine

摘　　要：目的了解女性系统性红斑狼疮(SLE)患者血清Th相关细胞因子水平,并探讨其与患者病情发生、发展的关系。方法用采用双抗体夹心法检测女性SLE患者Th1相关细胞因子IL-2、IFN-γ和Th2相关细胞因子IL-4、IL-10。结果SLE患者血清IL-2、IFN-γ水平显著低于正常对照组(P<0.05),IL-4、IL-10水平显著高于正常对照组(P<0.01)。IL-2、IFN-γ、IL-4、IL-10与ANA、C3、C4、CRP、ACA、抗ds-DNA抗体水平及SLEDAI活动性评分均无相关性,经治疗后IL-2、IFN-γ水平在治疗后升高,IL-4和IL-10水平较治疗前下降。结论SLE患者IL-4、IL-10水平明显高于健康对照组,IL-2、IFN-γ水平明显低于健康对照组,支持SLE患者体内存在Th1细胞向Th2细胞转化,表现为以Th2细胞为主的免疫应答。Objective To investigate serum levels of Th related cytokine levels in female patients with systemic lupus erythematosus（SLE）, and to explore the relationship between Th related cytokines and genesis and development of SLE. Methods ELISA was employed for the levels of sera cytokine Interleukin-2 （ IL-2）, interferon-γ（ IFN-γ）, Interleukin-4 （IL-4） and Interleukin-10（IL-10）. Results Serum IFN-γ and IL-2 levels in active SLE patients were significantly lower than those in normal controls （ P 〈 0. 05 ） , while serum IL-4 and IL-10 levels were significantly higher（ P 〈 0.01 ）. No significant correlations were found between the levels of serum cytokines and serum ANA, C3, C4, CRP, ACA, anti-dsDNA antibody and SLEDAI. Conclusion Variations of IL-2, IFN-3,, IL-4 and IL-10 in SLE indicate that the shift of Th1 to Th2 as welt as Th2 cell dominated immune response present in patients with SLE.

关 键 词：女性 SLE 细胞因子 

分 类 号：R593.241[医药卫生—内科学]