球囊法^32P内放疗同步内化疗综合治疗脑胶质瘤的临床研究  

Balloon ^32p internal radiotherapy with concurrent local chemotherapy for brain glioma： a clinical evaluation

作　　者：付廷刚[1] 王艳芝[1] 相寿长[1] 宋杰[1] 许鹏[1] 

机构地区：[1]山东省临沂市沂水中心医院神经外科,276400

出　　处：《中华神经医学杂志》2009年第7期700-703,共4页Chinese Journal of Neuromedicine

摘　　要：目的比较研究单纯球囊法，2P内放疗和球囊法，^32P内放化疗对脑胶质瘤患者的临床疗效。方法将山东省临沂市沂水巾心医院收治的脑胶质瘤患者228例分为3组，A组64例为普通放疗组，B组93例为单纯球囊法，2P内放疗组，C组71例为球囊法^32P内放化疗组．比较3组患者治疗有效率，平均生存期及1、3、5年生存率，分析其疗效；比较3组患者治疗后的KPS评分，分析治疗副作用。结果C组患者治疗后疗效，平均生存期及1、3、5年生存率高于A组、B组．差异均有统计学意义（P〈0．05）；B组与A组、C组与A组治疗后KPS评分比较差异有统计学意义（P（0．05），而B组与C组差异无统计学意义（P〉0．05）。结论球囊法^32P内放疗治疗胶质瘤患者疗效明显优于普通放疗，球囊法^32P内放化疗疗效优于单纯球囊法^32P内放疗。普通放疗副作用明显大于单纯球囊法^32P内放疗和球囊法^32P内放化疗，而单纯球囊法^32P内放疗和球囊法^32P内放化疗副作用差异不大。Objective To evaluate the clinical efficacy of balloon ^32p internal radiotherapy with concurrent local chemotherapy in the treatment of brain glioma. Methods A total of 228 patients with brain gliomas were enrolled in this study. Of these patients, 64 received conventional radiotherapy （group A）, 93 received balloon ^32p internal radiotherapy （group B）, and 71 had internal radiotherapy with concurrent local chemotherapy （group C）. The response rates, average survival period, and the 1, 3, and 5-year survival rates were compared between the 3 groups to evaluate the clinical efficacy of the treatments. The Karnofsky＇s Performance Scores （KPS） after the treatments were also compared to assess the adverse effects associated with the treatments Results Significant differences were found in the response rates, average survival period and 1, 3, and 5-year survival rates between the 3 groups. The KPS scores after the treatment differed significantly between groups B and A and between C and A, but not between B and C. Conclusion Balloon ^32p internal radiotherapy produces significantly better effect than conventional radiotherapy, and concurrent local chemotherapy even further enhances the effect of balloon ^32p internal radiotherapy. Conventional radiotherapy results in greater adverse effects than the other two procedures, which produce comparable adverse effects.

关 键 词：球囊法 内放疗 内化疗 神经胶质瘤 

分 类 号：R686[医药卫生—骨科学]