结核感染T细胞斑点试验辅助诊断小儿肺结核的临床研究  

The clinical application of T.SPOT-TB test in diagnosis of childhood pulmonary tuberculosis

作　　者：张卫平[1] 韩文[2] 白玉峡[1] 多力坤[1] 罗琼[1] 

机构地区：[1]新疆医科大学第一附属医院儿科,新疆乌鲁木齐830054 [2]新疆克拉玛依市中心医院儿科,新疆克拉玛依834000

出　　处：《临床儿科杂志》2009年第7期635-637,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨结核感染T细胞斑点试验(T.SPOT-TB)在小儿肺结核诊断中的意义。方法对2006年10月-2007年12月新疆医科大学第一临床医院0～14岁75例疑似肺结核患儿进行T.SPOT-TB检测,其结果与最终诊断相比较,并与PPD试验、结核抗体检测结果进行对比。结果T.SPOT-TB灵敏度为80.6%,特异度为89.5%。在结核病组中,T.SPOT-TB阳性率显著高于PPD试验与结核抗体检测阳性率(48.4%、15%,P<0.01)。结论T.SPOT-TB诊断小儿肺结核敏感、快速、准确,对儿童肺结核有早期诊断价值。Objective To explore the clinical application of T.SPOT-TB test in diagnosis of childhood pulmonary tuberculosis. Methods Total of 75 children aged from 0 - 14 years suspected of pulmonary tuberculosis were enrolled and performed T.SPOT-TB test. The T.SPOT-TB results were compared with the final diagnoses as well as the results of PPD test and tuberculosis antibody test. Results The sensitivity and specificity of T.SPOT-TB test were 80.6%, 89.5% respectively. The positive rate of T.SPOT-TB test was significantly higher than those of PPD test and tuberculosis antibody test （48.4%, 15% ） in children with pulmonary tuberculosis （P 〈 0.01 ）. Conclusions T.SPOT-TB test is a sensitive, fast and accurate test to diagnose childhood pulmonary tuberculosis. It can be applied in early diagnosis of pulmonary tuberculosis in children.

关 键 词：结核感染T细胞斑点试验 肺结核 诊断 儿童 

分 类 号：R725.1[医药卫生—儿科]