川崎病血小板升高与血清血小板生成素、白介素3、白介素6的关系研究  

Elevated platelet in Kawasaki disease and association with serum thrombopoietin,interleukin-3,interleukin-6

作　　者：史宏[1] 李晓辉[1] 周敏[1] 李晓静[1] 徐鸣[1] 李丹[1] 冉丛兰[1] 

机构地区：[1]成都市儿童医院,四川成都610017

出　　处：《临床儿科杂志》2009年第7期649-652,共4页Journal of Clinical Pediatrics

基　　金：四川省卫生厅基金资助项目(No.981009)

摘　　要：目的分析川崎病(KD)患儿血小板数量与血小板生成素(TPO)、白介素3(IL-3)、白介素6(IL-6)的水平变化,探讨KD血小板升高的机制。方法川崎病患儿35例,正常对照儿童25例。全自动血细胞分析仪检测两组外周血血小板计数(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW),双抗夹心酶联免疫吸附法(ELISA)检测血清TPO、IL-3和IL-6水平。结果KD患儿急性期PLT数量有所增高,但与对照组比较,差异尚无统计学意义;恢复期PLT增高明显(P<0.001)。KD患儿急性期血清TPO、IL-3和IL-6水平明显增高,与对照组及恢复期比较,差异有统计学意义(P<0.001)。MPV在急性期也较恢复期及对照组明显增高(P<0.001)。相关分析显示,KD患儿血小板计数与TPO、IL-3、IL-6水平呈负相关,MPV与TPO和IL-6水平呈正相关。结论KD急性期血清细胞因子TPO、IL-3、IL-6等水平的升高可能是恢复期血小板数量增多的主要原因。Objective To study the number of platelet in children with Kawasaki disease and analyze its association with serum thrombopoietin （TPO）, interleukin-3 （IL-3） and interleukin-6 （IL-6）. Methods Thirty-five children with Kawasaki disease （KD） and 25 healthy children as control were recruited. Peripheral blood PLT, MPV, PDW were measured using automatic hematocyte analyzer and serum TPO, IL-3 and IL-6 levels were detected by ELISA methods. Results The number of platelet was slightly increased in acute phase （ （329.17± 111.88） ×10^9/L vs （275.12± 71.09） × 10^9/L, （P〉 0.05））, and significantly increased in convalescent phase （（528.54 ± 185.22） × 10^9/L vs （329.17 ± 111.88） × 10^9/L, （P 〈 0.001））. MPV in KD acute phase was also significantly higher than that in control group （（8.68 ± 1.33） fl vs （7.78 ± 1.03） fl, （P 〈 0.001））. The serum levels of TPO, IL-3 and IL-6 in acute phase were significantly increased than those in convalescent phase and those in control group. There were significant inverse correlations between the number of platelet and TPO, IL-3, IL-6 levels, and positive correlations between MPV and TPO, IL-6. Conclusions Elevation of serum TPO, IL-3 and IL-6 may be mainly responsible for thrombocytosis in Kawasaki disease.

关 键 词：川崎病 血小板 血小板生成素 白介素3 白介素6 

分 类 号：R725.4[医药卫生—儿科]