阻塞性睡眠呼吸暂停低通气综合征患者手术前后性功能变化  

Erectile function in patients with obstructive sleep apnea hypopnea syndrome after operation

作　　者：王德生[1] 黄建民[1] 赖海春[1] 李晨[1] 林树春[1] 徐香娜[1] 洪燕玲[2] 

机构地区：[1]福建医科大学附属协和医院耳鼻咽喉科,福州350001 [2]福建医科大学附属协和医院核医学科,福州350001

出　　处：《山东大学耳鼻喉眼学报》2009年第3期1-3,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：福建省科技厅(2005J041);教育厅课题资助(JA05261)

摘　　要：目的探讨内皮素(ET)和一氧化氮(NO)在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并性功能障碍发病中的作用。方法对OSAHS合并性功能障碍者30例和OSAHS性功能正常者32例手术前后测评其性功能、多导睡眠监测指标、血浆ET和血清NO,同时取健康男性10例作对照。结果1.OSAHS性功能障碍组和OSAHS性功能正常组的睡眠呼吸暂停低通气指数(AHI)、ET均高于健康对照组,最低血氧饱和度(SaO2)、NO均低于健康对照组(P<0.01)。OSAHS性功能障碍组的最低SaO2、NO低于性功能正常组,AHI高于性功能正常组(P<0.05)。两组ET差异无统计学意义(P>s0.05);2.OSAHS患者的国际勃起功能指数-5(IIEF-5)与最低SaO2和NO呈正相关,与AHI和ET呈负相关(P<0.05);3.OSAHS合并性功能障碍组手术后与手术前比较,AHI和ET均降低,IIEF-5、最低SaO2和NO升高(P<0.01)。结论手术治疗可以改善OSAHS合并性功能障碍患者的性功能。NO在OSAHS患者并发性功能障碍的过程中发挥一定作用。Objective To explore the role of endothelin （ET） and nitric oxide （NO） in the pathogenesis of erectile dysfunction （ED） in obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods The International index of erectile function （IIEF- 5 ）, plasma ET, serum NO and polysemnographic （PSG） parameters in 30 OSAHS patients with accompanied erectile dysfunction and 32 normal erectile OSAHS patients were determined before and after operation. 10 normal subjects served as controls. Results 1. Compared with normal people, the apnea hypopnea index （AHI） and ET were increased in OSAHS patients with or without ED, while the lowest SaO2 and NO were decreased （ P 〈0.01）. The lowest SaO2 and NO in OSAHS patients with ED were lower than those in OSAHS patients without ED, AHI in OSAHS patients with ED was higher than that in OSAHS patients without ED （ P 〈 0.05）. There was no significant difference in ET in the two groups（ P 〉 0.05）. 2. In OSAHS patients , IIEF- 5 positively correlated with the lowest SaO2 and NO and negatively correlated with AHI and ET （ P 〈 0.05）. 3. In OSAHS patients with ED, AHI and ET were decreased after the operation, while IIEF-5, the lowest SaO2 and NO were increased after the operation （P 〈 0.01 ）. Conclusion Operation is effective for OSAHS patients with accompanied erectile dysfunction. NO may play a role in the pathogenesis of OSAHS-induced erectile dysfunction.

关 键 词：睡眠呼吸暂停 阻塞性 勃起功能障碍 手术 内皮素 一氧化氮 

分 类 号：R766.7[医药卫生—耳鼻咽喉科] R698.1[医药卫生—临床医学]