吲哚氰绿测定和肝纤维化定量评估肝储备功能的研究  

Evaluaton of liver functional reserve by quantitative assessment of hepatic fibrosis and indocyanine green measurement

作　　者：杨斌[1] 鲁建国[1] 杜锡林[1] 江雪[1] 

机构地区：[1]第四军医大学唐都医院普通外科,陕西西安710038

出　　处：《中国普通外科杂志》2009年第7期727-730,共4页China Journal of General Surgery

摘　　要：目的探讨吲哚氰绿和肝纤维化定量测定对评价肝储备功能的价值。方法制备大鼠肝硬化模型,测定吲哚氰绿15min潴留率(R15ICG)并使用计算机辅助数字图像分析法检测肝纤维化程度。分析R15ICG与肝纤维化定量评估间的关系,以及两者与肝功能测定间的关系。结果R15ICG和肝纤维化两指标在对照组、造模8周组和10周组之间差异有统计学意义(P<0.01)。R15ICG和Child-Pugh评分系统与肝纤维化百分比之间呈直线正相关(r=0.75,0.533;P<0.05)。结论吲哚氰绿和肝纤维化定量评估肝功能是较好的指标;两者联合使用有助于全面评价肝脏功能状态。Objective To investigate the value of quantitative assessment of hepatic fibrosis and indocyanine green measurement in predicting hepatic functional reserve in rats with liver cirrhosis. Methods Female Wister rats were divided into normal control and cirrhotic group, and cirrhotic models were established. Quantitative assessment of hepatic fibrosis was done by use of computer-assisted digital image analysis, and R151CG was measured. Results Differences of R151CG and quantitative assessment of hepatic fibrosis between the two groups at 8 and 10 weers after hepatic fibrosis model was established were statistically significant （P〈 0.01 ）. Quantitative assessment of hepatic fibrosis had a positive correlation （ r = 0. 75 and 0. 533, P 〈 0.05 ） with R151CG and Child-Pugh score. Conclusions Combining quantitative assessment of hepatic fibrosis with indocyanine green measurement is helpful for total assessment of liver functional reserve.

关 键 词：肝硬化 吲哚氰绿 肝储备功能 大鼠 

分 类 号：R657.3[医药卫生—外科学]