小于胎龄儿生后早期血浆游离卡尼汀与血糖、血脂的关系  

Relationship between plasma free carnitine and serum glucose,lipids in small for gestational age infants in early postnatal period

作　　者：刘艳明[1] 农光民[1] 陈文强[2] 钟丹妮[1] 

机构地区：[1]广西医科大学第一附属医院儿科 [2]广西医科大学医学实验中心

出　　处：《中国妇幼保健》2009年第22期3099-3101,共3页Maternal and Child Health Care of China

摘　　要：目的:了解小于胎龄儿生后早期血浆游离卡尼汀(CT)与血糖、血脂及主要体格测量指标的关系。方法:64例小于胎龄儿作为研究对象,30例足月适于胎龄儿作为对照组。所有研究对象生后早期未喂养前采集静脉血,并测量身长、体重、头围、腹围。采用高效液相色谱法(HPLC)测定血浆卡尼汀浓度,全自动生化分析仪常规检测血糖、血脂、白蛋白。应用SPSS 13.0软件进行统计学分析。结果:早产小于胎龄儿组(A组)血浆卡尼汀浓度为(38.67±12.75)μmol/L,足月小于胎龄儿组(B组)为(45.31±16.47)μmol/L,足月适于胎龄儿组(C组)为(54.17±18.35)μmol/L,3组比较差异有统计学意义(F=7.82,P<0.05),与另2组比较,早产小于胎龄儿组卡尼汀浓度更低。匀称型SGA血浆卡尼汀浓度比非匀称型SGA组低,差异有统计学意义(t=2.95,P<0.01)。小于胎龄儿血浆卡尼汀与HDL-C(r=0.46,P<0.05)、与ApoB(r=0.42,P<0.05)、G lu(r=0.52,P<0.05)、体重(r=0.51,P<0.05)、腹围(r=0.47,P<0.05)呈正相关,与TG(r=-0.44,P<0.05)、LDL-C(r=-0.57,P<0.05)呈负相关。结论:小于胎龄儿生后早期血浆游离卡尼汀浓度下降,早产小于胎龄儿更明显。小于胎龄儿生后早期血浆游离卡尼汀水平与血糖及血脂水平有关,与出生体重及腹围有关,小于胎龄儿生后早期卡尼汀的降低与葡萄糖及脂肪代谢紊乱有关。监测小于胎龄儿血浆游离卡尼汀浓度及适量补充卡尼汀对于防治生后早期代谢紊乱可能有益。Objective： To explore the relationship between plasma free carnitine and serum glucose, lipids in small for gestational age （SGA） infants in early postnatal period. Methods： 64 SGA infants and 30 full- term appropriate for gestational age （AGA） infants were selected as study group and control group. The height, birth weight, head circumference and abdomen circumference were measured. The plasma carnitine level was detected by high performance liquid chromatography （HPLC） , while the levels of serum glucose, lipids and albumin were detected by automatic biochemical analyzer. SPSS13. 0 software was used to analyze the data. Results： The levels of plasma carnitine in premature SGA, full - term SGA and full - term AGA were （ 38. 67± 12. 75 ） μmol/L, （45.31 ± 16. 47 ） μmol/L and （ 54. 17 ± 18. 35） μmol/L, there was significant difference among three groups （F =7.82, P 〈0. 05） , compared to the other groups, the level of carnitine in premature SGA was the lowest. The level of carnitine in dissymmetric SGA was lower than that in symmetric SGA （ t = 2. 95, P 〈 0.01 ） . There was positive correlation between plasma carnitine level and HDL - C （T =0. 46, P 〈0. 05）, ApoB （T =0. 42, P 〈0. 05）, glucose （y = 0. 52, P 〈 0. 05 ）, birth weight （ y = 0. 51, P 〈 0. 05 ）, abdomen circumference （ y = 0. 47, P 〈 0. 05 ） , while there was neg- ative correlation between TG （ T = - 0. 44, P 〈 0. 05 ） , LDL - C （ γ = - 0. 57, P 〈 0. 05 ） and plasma carnitine level. Conclusion： The level of plasma free carnitine of SGA in early postnatal period decreases, especially premature SGA. The level of plasma free carnitine in SGA in early postnatal period is related to serum glucose, lipids, birth weight and abdomen circumference. Monitoring of plasma free earnitine and proper supplement of carnitine may be helpful to prevent the onset of abnormal metabolism.

关 键 词：卡尼汀 小于胎龄儿 血糖 血脂 

分 类 号：R715.8[医药卫生—妇产科学]