不同药物对豚鼠实验性呼吸衰竭疗效的比较研究  

The effect of different medicines on the experimental respiratory failure in guinea pig

作　　者：俞志成[1] 李树清[1] 张颖[1] 彭艳程[1] 

机构地区：[1]昆明医学院基础学院病理生理学教研室,云南昆明650031

出　　处：《中国民族民间医药》2009年第13期17-19,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:比较不同药物对豚鼠呼吸衰竭的治疗效果,探索一种能改善呼吸功能及稳定动脉血PaO2的药物。方法:建立豚鼠呼吸衰竭模型,按不同药物组给药,用药期间在规定时间点PaO2的变化。结果:组织胺导致的急性呼吸衰竭模型与临床I型呼衰相似。尼可刹米、氨茶碱及地塞米松对豚鼠呼吸衰竭具有不同程度的治疗作用,以上各药物组与呼衰组比较均具有显著性差异(P<0.01)。结论:尼可刹米、氨茶碱及地塞米松具有升高PaO2和改善实验性呼吸衰竭的效应。Aim： To compare therapeutic effect of several medicines on respiratory failure in guinea pig, and explore a medicine that can improve respiratory function and stabilize PaO2. Method： The animal model of respiratory failure in guinea pig was set up, and several medicines were treated according to different medicines group, and the blood specimen was collected to monitor PaO2 at different time points. Result： The acute respiratory failure model which is induced by Histamine is similar to clinical I type respiratory failure. The Nikethamide, Aminophylline and Dexamethasone have therapeutic effects on respiratory failure in varying degrees. Above all groups have significant difference, compared with control group. （P〈0.01） . Conclusion： The Nikethamide, Dexamethasone and Aminophylline can increase PaO2 and improve respiratory function.

关 键 词：氨茶碱 尼可刹米 沙丁胺醇 地塞米松 呼吸衰竭 氧分压 

分 类 号：R285.5[医药卫生—中药学]