咪唑安定用于硬膜外麻醉辅助用药遗忘作用的研究  

Midazolam assisted intraspinal anesthesia for the amnesia forgotten role of administration

作　　者：黄安宁[1] 陈娜[1] 胡彬[1] 丁莉莉[1] 刘丽萍[1] 

机构地区：[1]武警北京总队医院麻醉科,北京100027

出　　处：《武警医学院学报》2009年第9期770-772,共3页Acta Academiae Medicinae CPAPF

摘　　要：【目的】研究咪唑安定作为椎管内麻醉辅助用药在镇静遗忘方面的情况。【方法】选择行硬膜外麻醉的患者90例,根据术中辅助用药种类不同随机分为三组:咪唑安定组(A组)、地西泮组(B组)和氟哌啶组(C组)。监测入手术室时和给予相关药物后各时间点的平均动脉压(MAP)、心率(HR)和氧饱和度(sPO2);记录给药后达到镇静需要的时间并对患者的遗忘情况进行评分。【结果】A组、B组、C组用药后的MAP、HR和sPO2无显著性差异(P>0.05)。A组(咪唑安定组)使患者达到OAA/S评分标准3级的时间明显短于B组和C组(P<0.05)。A组产生遗忘效果优于B组和C组(P<0.05)。【结论】咪唑安定作为椎管麻醉前用药具有相对快速的起效时间和完善的遗忘效果。[Objective] To observe the effects of midazolam on sedation and amoesia in intraspinal anesthesia. [Methods] Ninety patients were randomly divided into three groups： group A received midazolm, group B received Diazepam and group C received droperidol. MAP, HR, sPO2 monitorelg before and after administration. Record the time of reaching sedation and hypnosis and scored the effect of amnesia. [Results] The value of MAP, HR, sPO2 had no difference amongst group A, B and C after administration （ P 〉 0.05） . It took shorter time in group A than group B and C that OAA/S reach the scale of 3 （ P 〈 0.05） . The amnesia effect score in group A was higher than group B and C （ P 〈 0.05） . [Conclusions] Midazolam has the quicker effect and more consummate amnesia effect in intraspinal anesthesia.

关 键 词：咪唑安定 硬膜外麻醉 镇静 遗忘 

分 类 号：R614.4[医药卫生—麻醉学]