顺式阿曲库铵在小儿腹腔镜手术中的应用  

CIS-ATRACURIUM USED IN LAPAROSCOPIC SURGERY ON CHILDREN

作　　者：梁仁强[1] 熊理锋[1] 谭瑞丹[1] 

机构地区：[1]湛江中心人民医院,广东湛江524037

出　　处：《现代医院》2009年第8期25-26,共2页Modern Hospitals

摘　　要：目的探讨不同剂量的顺式阿曲库铵应用于小儿腹腔镜下手术的药效学特点。方法择期行腹腔镜下手术的小儿80例,随机分成2组,分别静注2ED95(Ⅰ组)或3ED95(Ⅱ组)的顺式阿曲库铵,记录两组肌松阻滞时效并对插管条件进行评级,观察阻滞起效时间、TOF无反应期、阻滞维持时间、肌松恢复指数与体内作用时间。结果Ⅱ组气管插管时肌松阻滞和插管条件较Ⅰ组好;肌松起效时间Ⅱ组较Ⅰ组短;TOF无反应期、阻滞维持时间和体内作用时间两组比较均有显著性差异;两组肌松恢复指数无显著差异。结论3ED95诱导剂量顺式阿曲库铵应用于小儿起效快且插管条件佳,且TOF无反应期、阻滞维持时间和体内作用时间均较2ED95剂量顺式阿曲库铵的时间长;两组恢复指数无明显差异。Objective To observe the pharmacodynamie characteristics of different doses of eis - atracurium used in laparoscopic surgery on children. Methods 80 cases of selective laparoscopic surgery on children were randomly divided into 2 groups, 2 ED95（ Ⅰ group） or3 ED95（ Ⅱ group） of cis - atracurium were intravenously given respectively. Record two group＇ s muscle block time -effect and intubation conditions to observe the onset time of block, TOF -free response period, duration of anesthesia, muscle relaxation index and time in vivo recovery. Results Tracheal intubation in group Ⅱ with muscle relaxant block and intubation conditions better than group Ⅰ ;onset time of muscle relaxation in group Ⅱ shorter than that in group Ⅰ ;TOF non - response period, maintain time of block and the time of function in vivo of two groups were different significantly; muscle recovery index were not significantly different Conclusion 3ED95 inducing dose of cis -atracurium effect on children with fast and excellent intubation conditions, and no response to TOF period and maintain time of block and the time of function in vivo longer than 2ED95 dose cis - atracurium ;two groups had no significant difference in recovery index.

关 键 词：小儿 腹腔镜 顺式阿曲库铵 治疗应用 

分 类 号：R971.8[医药卫生—药品] R735.2[医药卫生—药学]