N,N＇-二{亚烷基氧羰基苯基-5-[10，15，20-三(4-氯苯基)]卟啉基}-5-氟尿嘧啶的合成与表征  

Synthesis and Characterization of N,N'-bis{alkyleneoxocarbonylphenyl-5-[10,15,20-tri(4-chlorophenyl)]porphyrin-5-fluorouracil

作　　者：郝晓伶[1] 王涛[2] 韩士田[1] 刘彦钦[1] 

机构地区：[1]河北师范大学化学与材料科学学院,石家庄050016 [2]河北科技大学理学院,石家庄050018

出　　处：《化学通报》2009年第7期669-672,共4页Chemistry

基　　金：河北省自然科学基金项目(203147);国家自然科学基金项目(20601007)资助

摘　　要：用对氯苯甲醛和对羧基苯甲醛为原料,合成了周边含羧基苯基的不对称卟啉中间体,然后再与5-氟尿嘧啶反应,合成了两种亚烷基链长不同的标题化合物,产率为22.1%和19.8%。产物结构由元素分析、红外光谱、紫外可见光谱、核磁共振谱和质谱表征确认。同时对目标化合物的合成条件进行了研究,结果表明,在以DMF为溶剂、反应温度在125℃、反应时间8h条件下,反应产率较高。Using p-chlorobenzaldehyde and p-carboxylbenzaldehyde as the starting materials, the porphyrin intermediate containing carboxyphenyl in peripheral was synthesized, then it was reacted with 5-fluorouracil, the titled compounds with different alkylene length were synthesized with yields 22.1% and 19.8%, respectively. The structures of the products were characterized by elemental analysis, UV-Vis, IR, ^1 H NMR and MS. The results showed that the yield was higher when DMF was used as the solvent at 125℃ for 8h.

关 键 词：卟啉 5-氟尿嘧啶 合成 表征 

分 类 号：TQ463.53[化学工程—制药化工]