大鼠原位单向肠灌注模型研究淫羊藿苷肠吸收代谢特性  

Absorption and Metabolism of Icariin in the in Situ Single-Pass Perfused Rat Intestinal Model

作　　者：蔡垠[1,2] 贾晓斌[1,2] 陈彦[1] 范晨怡[1] 黄丽霞[1] 

机构地区：[1]江苏省中医药研究院江苏省现代中药制剂工程技术研究中心,南京210028 [2]江苏大学,江苏镇江212013

出　　处：《中国药学杂志》2009年第13期985-988,共4页Chinese Pharmaceutical Journal

基　　金：国家自然基金资助项目(30572372);江苏省中医药局专项(H05120)

摘　　要：目的利用大鼠原位单向肠灌注模型研究淫羊藿苷肠吸收代谢特性。方法采用大鼠四段单向在体肠灌流模型灌注淫羊藿苷溶液,采用HPLC对灌注前后淫羊藿苷含量以及代谢产物进行测定。结果淫羊藿苷各肠段的渗透系数存在显著性差异,且淫羊藿苷在肠内大部分被代谢为两种代谢产物。结论淫羊藿苷在肠道内具有较高的表观渗透系数,是因为大量被代谢,从而原型药物进入体循环的量极少,生物利用度低。OBJECTIVE To study the absorption and metabolism of icariin in the perfused rat Intestinal model. METHODS A perfused rat intestinal model were used for the study. Icariin and its metabolite were determined by HPLC. RESULTS Permeability coefficient of each intestine were significant different. Icariin was metabolited into two metabolites. CONCLUSION Icariin was metabolited greatly, so that icariin has high permeability coefficient but low bioavailability.

关 键 词：淫羊藿苷 吸收代谢 大鼠原位单向肠灌注模型 

分 类 号：R965[医药卫生—药理学]