血液透析对慢性肾功能衰竭患者血液中细胞因子的影响  

Hemodialysis on the cytokines in patients with chronic renal failure

作　　者：吴仁胜[1] 李时琪[1] 叶扬梅[1] 

机构地区：[1]巢湖市第二人民医院肾内科,安徽巢湖238000

出　　处：《皖南医学院学报》2009年第3期190-192,共3页Journal of Wannan Medical College

摘　　要：目的:探讨血液透析对慢性肾功能衰竭(CRF)患者血液中细胞因子的影响,为临床提前干预治疗提供必要的佐证。方法:选取自2006年1月～2008年10月在我院进行规律性透析的10名慢性肾功能衰竭患者组,分别于透析中0、120、240min同步留取血液样本,检测样本中的C-反应蛋白(CRP)、白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α),另随机选取10名健康志愿者作对照。结果:血液透析患者在血液透析过程中,CRP、IL-6及TNF-α均明显升高。结论:血液透析可引起患者体内炎症因子释放和/或合成增加,导致患者存在微炎症状态。Objective ： To investigate the effects of hemodialysis （ HD ） on serum inflammatory cytokine level in patients with chronic renal failure （CRF） for providing the necessary evidence with early intervention in this disease. Methods ：This study included 10 patients with CRF who had undergone regular hemodialysis in our hospital during Jan. 2006 and Oct. 2008. The blood samples were taken simultaneously at 0 min, 120min or 240 rain during hemodialysis for detecting C-reaction protein （ CRP ） , interleukin-6 （IL-6） and tumor necrosis factor-α （ TNF -α ） in the serum. Ten healthy volunteers were recruited for the controls. Results：The concentrations of CRP,IL-6 and TNF-α were increased significantly during a single HD session when compared with the healthy controls. Conclusion ： HD may result in the release and/or synthesis of cytokiues in patients with CRF and induce micro-inflammation.

关 键 词：血液透析 C-反应蛋白 肿瘤坏死因子-Α 白介素-6 

分 类 号：R692.5[医药卫生—泌尿科学]