纳洛酮对外伤性脑损伤患者血浆ET-1和CGRP影响的临床研究  

The Effect of Naloxone on Plasma ET-1 and CGRP Levels in Patients with Traumatic Brain Injury

作　　者：张春银[1] 官明[2] 蔡亮[1] 陈伯勋[1] 甘西伦[1] 

机构地区：[1]泸州医学院附属医院核医学科,四川泸州646000 [2]泸州医学院附属医院神经外科,四川泸州646000

出　　处：《标记免疫分析与临床》2009年第3期139-141,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨外伤性脑损伤患者血浆ET-1和CGRP变化以及纳洛酮治疗对血浆ET-1和CGRP的影响。90例外伤性脑损伤患者随机分为纳洛酮治疗组与常规治疗组,另取30名健康人作为对照组。用放射免疫分析法测定患者治疗前后血浆ET-1、CGRP含量。纳洛酮治疗组和常规治疗组治疗前血浆ET-1显著升高,治疗后明显下降,常规治疗组下降幅度明显小于纳洛酮治疗组(P<0.01);纳洛酮治疗组和常规治疗组治疗后血浆CGRP明显升高,纳洛酮治疗组升高幅度明显大于常规治疗组(P<0.01)。外伤性脑损伤患者血浆ET-1水平显著升高,CGRP水平显著降低;早期应用纳洛酮可显著降低ET-1和提高CGRP水平。初步研究显示,纳洛酮具有脑保护作用,伤后早期应用纳洛酮可改善病人预后。To investigate the effect of naloxone on the changes of plasma ET-1 and CGRP levels in patients with traumatic brain injury, ninety patients with traumatic brain injury were randomly divided into naloxone treated group and conventionally treated group（ both n =45 ）. The plasma levels of ETA and CGRP in both groups before and after treatment and in 30 healthy controls were measured by RIA. The results showed that the plasma levels of ET-1 were significantly increased in the patient before treatment and decreased markedly after treatment in both groups. The magnitude of decrease of the plasma ET-1 levels in the naloxone treated group was signifi- cantly higher than that in the conventionally treated group （P 〈 0.01 ）. The plasma levels of CGRP were significantly decreased in the patients before treatment and increased markedly after treatment in both groups. The magnitude of increase of the plasma CGRP levels in the naloxone treated group was significantly higher than that in the conventionally treated group（P 〈0.01 ）. The plasma ET-1 levels in patients with traumatic brain injury was remarkably increased and markedly decreased after treatment with naloxone. The plasma CGRP levels in patients with traumatic brain injury was remarkably decreased and markedly increased after treatment with naloxone. Naloxone has a favorable effect on patient with traumatic brain injury, it may protect the neural cells and improve their living quality.

关 键 词：脑损伤 纳洛酮 内皮素 降钙素基因相关肽 

分 类 号：R651.15[医药卫生—外科学]