别嘌醇抗痛风疗法加用塞来昔布致患者尿蛋白阳性  

A positive urine protein value occurring in a patient after addition of celecoxib to allopurinol-containing regimen for gout

作　　者：张芳[1] 陈安进[1] 

机构地区：[1]青岛市市立医院药学部,山东青岛266011

出　　处：《药物不良反应杂志》2009年第3期217-218,共2页Adverse Drug Reactions Journal

摘　　要：1例54岁男性肾移植术后患者,因痛风3年来一直应用别嘌醇、泼尼松和碳酸氢钠治疗。近1个月来,因痛风症状加重住院治疗,并加用塞来昔布0.2 g,2次/d。治疗前检查肾功能正常,尿蛋白阴性。治疗3 d后,患者出现尿蛋白阳性及尿中泡沫增多。停用塞来昔布,3 d后尿中泡沫减少,尿蛋白转阴性。A 54-year-oht male renal transplant recipient received allopurinol, prednisone, and sodium bicarbonate for gout in the past three years. In recent one month, his gout symptoms were exacerbated, then he was hospitalized and celeeoxib 0.2 g twice daily was added to his regimen. The patient＇s renal function was normal and his urine protein was negative before treatment. After three days of therapy, he developed a 1 ＋ urine protein and increased foamy urine. Celecoxib was stopped. After 3 further days, his foamy urine decreased and his urine protein became negative.

关 键 词：塞来昔布 别嘌醇 不良反应 肾损害 尿蛋白 

分 类 号：R595.3[医药卫生—内科学]