专用四肢关节磁共振在兔膝关节软骨缺损修复中的应用  

Research of Low Field Intensity Joint MR Scan in Rabbit Knee Articular Cartilage Defect Repair

作　　者：曾旭文[1] 梁治平[1] 陈鸿辉[2] 钟敏之[1] 陈松[1] 杨小红[2] 梁佩红[2] 

机构地区：[1]暨南大学医学院附属第四医院放射科,广东广州510220 [2]暨南大学医学院附属第四医院创伤研究所,广东广州510220

出　　处：《中山大学学报（医学科学版）》2009年第4期413-417,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省医学科学研究基金(A2007509);广州市科技攻关项目(200623-E0371);广州市卫生局重点项目(2006-ZDi-03);广州市医药卫生重点项目(2006-ZDi-04)

摘　　要：【目的】研究新西兰成年白兔膝关节软骨缺损修复后的低场强专用四肢关节磁共振诊断价值。【方法】40只兔左膝关节随机分为两组:A组:通过手术形成软骨缺损,不植入Ⅱ型胶原;B组:缺损内填充Ⅱ型胶原,术后2、6、12、18周分别行专用关节MR扫描,扫描后取材,行组织学检查。【结果】A、B两组手术区均显示有规律的动态MR改变,结合组织学分析,A组是软骨缺损的自我修复过程,B组是填充物的成熟过程。12周时两组均可见关节软骨信号,B组软骨信号较光滑,与组织学结果相符。【结论】专用四肢关节MR检查具有评价关节软骨修复的潜力,可望成为一种无创的软骨修复术疗效评价方法。[ Objective ] To research the diagnostic value of low field intensity joint MR in majority New Zealand albino rabbit knee articular cartilage defect repair. [Method] 40 New Zealand albino rabbit left knee were divided into two group： A group： cartilage defect were made by operation, but type II collagen were not implant; B group： type II collagen were implant in the defect. Two group of rabbit left knees were scan in joint MR at 2,6,12, and 18 weeks after operations, histological anatomy were done after MR scan. [Results] Two group of rabbit knees showed regular dynamic MR appearance, associated with the histological anatomy, the cartilage defect nature repair process were seen in A group; the packing material maturation process were seen in B group. 12 weeks after operations, articular cartilage signal were seen in both two groups, articular cartilage signal in B group were smooth. [Conclusion] Low field intensity joint MR is potential in articular cartilage defect repair evaluation, it maybe a diagnostic method in articular cartilage defect repair without trauma.

关 键 词：磁共振成像 软骨缺损 Ⅱ型胶原 

分 类 号：R816[医药卫生—放射医学]