雌、孕激素受体分布变化对分娩发动的影响  

Influence of alterations in distributions of estrogen and progestogen receptors on initiation of parturition

作　　者：吴晓荣[1] 王婷[1] 屈新中[1] 

机构地区：[1]西安交通大学第一附属医院妇产科,陕西西安710061

出　　处：《中国妇幼健康研究》2009年第4期449-451,共3页Chinese Journal of Woman and Child Health Research

摘　　要：雌、孕激素与相应受体结合，发挥特定的生物学效应在分娩发动中的作用日益受到重视。它们有可能是参与分娩发动起始环节的一部分。目前研究已经证实，孕激素能够抑制雌激素的作用，通过维持子宫的静息状态来维持妊娠。正常足月妊娠末至分娩发动前，孕激素的表达水平并未显著降低；而孕激素受体亚型A／B的比值增加，抑制了活性型孕激素受体亚型B的转录活性，同时也诱导雌激素受体的表达增加。从而介导功能性孕激素撤退和雌激素功能的激活，子宫的静息状态被打破，开始协调收缩，分娩发动。因此，雌激素受体／孕激素受体的表达变化在分娩发动的环节中可能比雌、孕激素有着更为重要的意义。The roles of bindings of estrogen and progesterone to corresponding receptors to exert their certain biological effects have attracted more attention. Maybe, this is a part of steps of initiation of labor. So far, it has already confirmed that progesterone can inhibit estrogenic function to maintain quiescent condition of the uterus and keep pregnancy on. From late pregnancy to initiation of parturition, the expression level of progesterone is not decreased significantly, while the ratio of subtypes of progesterone receptor （PR） PRA/PRB increased, which inhibits transcriptional activity of active progesterone receptor subtype PRB, meanwhile, induce increased expression of estrogen receptor（ER）. The distribution alterations of progesterone recetors induce functional progesterone withdrawal and activation of estrogen function. Finally, the quiescent condition of myometrium is surmounted, the labor then starts. So, alterations in expressions of ER and PR play more important roles in initiation of parturition than estrogen and progesterone themselves.

关 键 词：雌激素受体 孕激素受体 受体亚型 分娩发动 

分 类 号：R714.3[医药卫生—妇产科学]