塞克硝唑片治疗细菌性阴道病的临床分析  

Clinical evaluation of secnidazole tablet in treatment of bacterial vaginosis

作　　者：何先红[1] 

机构地区：[1]湖南省资兴市立医院妇产科,423400

出　　处：《中国实用医药》2009年第8期25-26,共2页China Practical Medicine

摘　　要：目的评价塞克硝唑片治疗细菌性阴道病的有效性和安全性。方法256例细菌性阴道病患者随机分成对照组126例和试验组130例,分别给予甲硝唑片和塞克硝唑片口服;停药后3～5d及停药后下次月经来潮干净后3～7d比较两组的临床疗效,比较两组3个月内的复发率;并观察两组的不良反应的发生情况。结果停药后3～5d,对照组的治愈率和有效率分别为64.3%和82.5%,试验组的治愈率和有效率分别为76.2%和91.5%;停药后下次月经来潮干净后3～7d对照组的治愈率和有效率分别为65.9%和83.3%,试验组的治愈率和有效率分别为78.5%和92.3%;两组比较有显著性差异(P<0.05)。对照组和试验组的复发率分别为12.0%和14.7%(P>0.05)。两组间的不良反应发生率无显著性差异。结论塞克硝唑片治疗细菌性阴道病安全有效。Objective To evaluate the efficacy and safety of secnidazole tablet in treatment of bacterial vaginosis. Methods 256 patients with bacterial vaginosis were randomly divided into control group （ n = 126 ） and trial group （n = 130）. Control group were given metronidazole tablets and trial group were given secnidazole tablets. The clinical efficacy was compared between two groups 3 - 7 days after the end of treatment and 3 - 7 days after menorrhea, respectively. The relapse rate during 3 months after the end of treatment between two groups was compared. The side effects in two groups were observed. Results 3 - 7 days after the end of treat- ment,the cure rate and efficacy rate were 64. 3% and 82. 5% in control group and 76. 2% and 91.5% in trial group, respectively. 3 -7 days after menorrhea, the cure rate and efficacy rate were 65.9% and 83.3% in control group and 78. 5% and 92. 3 % in trial group, respectively. There was a significant difference between two groups. The relapse rate wasl2. 0% in control group and 14. 7% in trial group （P 〉 0. 05 ）. The incidence of side effects between two groups was not significantly different. Conclusion Secnidazole tablet is efective and safe in the treatment of bacterial vaginosis.

关 键 词：塞克硝唑 甲硝唑 细菌性阴道病 

分 类 号：R711.3[医药卫生—妇产科学]