奶牛乳房炎与核转录因子κB基因的表达调控  

Modulation of NF-κB in Mastitis of Dairy Cow

作　　者：袁芳[1,2,3] 刘明军[1,2] 白杰[1,2] 林嘉鹏[1,2,3] 侯敏[1,2,3] 

机构地区：[1]新疆畜牧科学院生物技术研究中心,乌鲁木齐830000 [2]农业部草食家畜繁育生物技术重点开放实验室,乌鲁木齐830000 [3]新疆农业大学农学院生命科学系,乌鲁木齐830052

出　　处：《中国畜牧兽医》2009年第7期129-133,共5页China Animal Husbandry & Veterinary Medicine

基　　金：国家973前期研究专项(2007LS700204);国家自然科学基金课题(30760161)

摘　　要：核转录因子(nuclear factor-κB,NF-κB)是一个广泛存在于哺乳动物细胞中的转录因子,参与机体的免疫反应、细胞黏附、细胞分化、细胞增殖与凋亡及应激反应等。在奶牛感染乳房炎时,大部分涉及中性白细胞移行和激活的炎性蛋白质的编码基因在他们的启动子区都包含一个可结合NF-κB的κB位点,因此在一定程度上依赖NF-κB调控这些基因的表达。笔者详细的阐述NF-κB基因在奶牛乳房炎发病过程中的特点、作用和表达机制,为从分子水平认识和治疗奶牛乳房炎提供一定的文献支持。Nuclear factor-κB （NF-κB） is widespread in mammal which is responsible for immune response, cell adhesion, differentiation, proliferation and apoptosis. Most of the genes encoding inflammatory proteins involved in neutrophil migration and activation have been shown to contain κB sites for the NF-κB within their promoter region and therefore partly depend on NF-κB for their expression,suggesting that this transcription factor might play a critical roles in the pathophysiology of mastitis. This paper summarized NF-κB characteristic, function and expression mechanism, for the purpose to give some fundamental messages to understand the mechanisms of dairy mastitis.

关 键 词：NF-ΚB 奶牛乳房炎 奶牛 

分 类 号：S856.5[农业科学—临床兽医学]