鸡IFN-γ基因克隆表达及其抗球虫研究进展  

Chicken IFN-γ Gene Cloning and Expression and the Study Progress of Anti-coccidia Effect of IFN-γ

作　　者：雷娜[1] 陈书明[1] 

机构地区：[1]山西农业大学动物科技学院,太谷030801

出　　处：《中国畜牧兽医》2009年第7期178-181,共4页China Animal Husbandry & Veterinary Medicine

基　　金：山西省科技攻关项目(052011);山西高校科技研究开发项目(20051222);山西农业大学科技创新基金项目(200002)

摘　　要：鸡干扰素主要由活化的T细胞、NK细胞产生,具有广谱抗病毒、抗肿瘤和免疫调节等作用。鸡干扰素-γ基因已经被成功克隆并在Vero细胞和大肠杆菌等表达系统中表达,并且被证明与鸡球虫病的免疫有关,它可激活巨噬细胞,增强K细胞、NK细胞的抗感染作用。另外,ChIFN-γ可用作免疫增强剂,具有广泛的应用前景。Chicken interferon comes from the activated T cells, NK cells. It has many functions, such as broad-spectrum anti-viral, anti-tumor and the role of immunity regulation. Chicken interferon-γ gene has been cloned successfully in vero cells and E. coli and so on. Also chicken interferon-γ gene has been expressed and proved to enhance the immunity function against chicken coccidiosis. It could activate macrophages and reinforce the role of anti-infective of K cells, NK cells. In addition, ChlFN-γcan be used as immunoenhancer, which has a wide range of application.

关 键 词：鸡 干扰素-Γ 基因表达 球虫病 

分 类 号：Q785[生物学—分子生物学]