肌钙蛋白I和肌红蛋白定量检测在心血管疾病中的应用研究  

Troponin I and myoglobin in the quantitative detection of cardiovascular disease in the applied research

作　　者：唐浩熙[1] 李介华[1] 张小勇[1] 陆灶其[1] 梁大立[1] 李冬秀[1] 

机构地区：[1]暨南大学医学院第五附属医院暨广东省清远市人民医院,511500

出　　处：《中国实用医药》2009年第5期13-15,共3页China Practical Medicine

基　　金：广东省清远市科技局计划项目(项目编号:20041721)

摘　　要：目的探讨肌钙蛋白I(cTnI)、肌红蛋白(Mb)定量检测在心血管疾病中的临床价值。方法A组:健康对照组100例,男女各50例,平均52岁。于早晨空腹取静脉血3ml送检。B组:冠心病患者153例,男94例,女59例,于早晨空腹取静脉血3ml送检;C组:急性心肌梗死(AMI)无合并症组158例,其中男121例,女37例,年龄24～86岁,平均66岁,于胸痛发作后3h抽静脉血3ml送检。D组:AMI合并心力衰竭组146例,男118例,女28例。年龄40～84岁,平均65岁,于胸痛发作后3h临床表现为有心力衰竭症状时抽静脉血3ml送检。A、B、C、D组全部采用全自动微粒子化学发光分析仪定量检测cTnI、Mb。结果A组cTnI浓度为(0.27±0.18)μg/L,Mb浓度为(42±21)μg/L;B组cTnI浓度为(0.45±0.17)μg/L,Mb浓度为(46±20)μg/L,A组与B组差异无统计学意义(P=0.52,P>0.5);C组cTnI浓度为(16.71±14.19)μg/L,Mb浓度为(522±392)μg/L;D组cTnI浓度为(25.01±19.12)μg/L,Mb浓度为(936±712)μg/L;B组与C、D组比较差异具有统计学意义(P=0.000,P<0.01);C组与D组比较差异具有非常显著性的意义(P=0.002,P<0.01)。结论cTnI、Mb对冠心病患者继发急性心肌梗死有很高的诊断价值,对有胸痛症状的冠心病患者检测cTnI、Mb可早期诊断AMI,及时溶栓和治疗。从C组和D组的结果来看,D组cTnI、Mb比C组显著增高,因此,当cTnI浓度达到(25.01±19.12)μg/L,Mb浓度达到(936±712)μg/L时,可合并心力衰竭。Objective Discussion troponin I （cTnI）, myoglobin （Mb） in the quantitative detection of cardiovascular disease in clinical value. Methods Group A ： control group of 100 healthy me n and women of all 50 people, average age 52 years old. Venous access in the morning on an empty stomach 3 ml inspection. Group B： 153 patients with coronary heart disease, 94 men, 59 women, on an empty stomach in the morning, take blood 3 ml inspection; C： acute myocardial infarction （AMI） without complications group of 158 people, 121 cases of men, 37 women patients, aged 24-86 years old, the average 66-year-old, at 3 hours after onset of chest pain pump blood 3 ml inspection. D Group： AMI heart failure combined group of 146 people, 118 men and 28 women. Age 40-84 years old, the average 65-year-old, at 3 hours after chest pain onset of clinical per- formance for heart failure symptoms when blood pumping 3 ml inspection. A, B, C, D groups the use of fully automated microparticle chemiluminescence analyzer quantitative detection of cTnI, Mb. Results A group of cTnI concentration of （0.27±0.18）μg/L, Mb concentration of（42±21）μg/L; B group cTnI concentration of （0.45±0.17）μg/L, Mb concentration of（46±20）μg/L, A and group B group differences There was no significant meaning （P=0.52, P〉0.5） ; C group cTnI concentration of （16.71±14.19）μg/L, Mb concentration of（522±392）μg/L; D group cTnI concentration of（25.01±19.12）μg/L, Mb concentration To （936±712）μg/L; B and Group C, D group differences in a very significant meaning （P=0.000, P 〈 0.01） ; C Group D and group differences in a very significant meaning （P=0.002, P 〈 0.01）. ConclusionS cTnI, Mb of coronary heart disease in patients with acute myocardial infarction secondary diagnosis of a very high value on the symptoms of chest pain in patients with coronary heart disease detection of cTnI, Mb to the early diagnosis of AMI, and thrombolytic therapy in a timely manner. From Group C and Group D results, D gro

关 键 词：肌钙蛋白I 肌红蛋白 急性心肌梗死 冠心病 定量 价值 

分 类 号：R54[医药卫生—心血管疾病] R541.4[医药卫生—内科学]