噬菌体治疗研究进展  

Recent Advance in Bacteriophage Therapy

作　　者：王盛[1] 童贻刚[1] 

机构地区：[1]军事医学科学院微生物流行病研究所病原微生物国家重点实验室,北京100071

出　　处：《微生物学通报》2009年第7期1019-1024,共6页Microbiology China

摘　　要：噬菌体发现之初,便被前苏联和东欧医学界用来治疗细菌感染。但是,随着抗生素时代的到来,人们慢慢忽略了对噬菌体的深入研究。近来,由于全球耐药菌感染率不断攀升,用抗生素治疗细菌感染面临了前所未有的挑战,一些科学家和临床工作者开始重新把注意力集中到噬菌体研究上来,并在这个领域取得了极大的进展,尤其是通过大量的实验证明:噬菌体可以有效地提高细菌感染的实验动物的存活率。本文就近几年国内外的科研工作者在噬菌体治疗领域所取得的进展做一综述。At the time of phage’s discovery, phage therapy was regarded as a possible treatment method against bacterial infection. Although phage therapy was used to treat and prevent bacterial infection in the former Soviet Union and Eastern Europe, it was abandoned by the West in the 1940s with the arrival of the antibiotic era. However, the ongoing evolution of bacterial multidrug-resistance has recently motivated the Western scientific community to reevaluate phage therapy for bacterial infections that are incurable by conventional chemotherapy. With the in-depth study of phages, it’s increasingly acknowledged that phages, as the medicine to cure bacterial infection, are convenient, safe and efficient therapeutics. This paper summarizes the recent years’ advanced researches in this area.

关 键 词：噬菌体 噬菌体治疗 细菌感染 

分 类 号：R456[医药卫生—治疗学]