选择性剪接在低氧应答中的调控作用  

Regulatory Role of Alternative Splicing in Hypoxia Response

作　　者：张秉怡[1] 宁斌[1] 李佩尧[1] 孟庆雄[1] 

机构地区：[1]昆明理工大学白龙校区生命科学与技术学院,昆明市650224

出　　处：《医学分子生物学杂志》2009年第4期369-373,共5页Journal of Medical Molecular Biology

摘　　要：细胞为适应低氧环境，其相关基因的表达方式发生了改变，其中选择性剪接在低氧应答调控过程中起到了重要的作用。低氧诱导因子介导的低氧应答信号通路在机体适应低氧环境过程中起到了十分重要的作用，低氧诱导因子剪接体通过此通路调控红细胞生成、血管生成、糖酵解等过程。而抑制性PAS蛋白质、脯氨酸羟化酶、促血管生长因子、芳香羟受体核转运蛋白剪接体则通过其它通路进行调控。选择性剪接不仅在低氧应答中起重要作用，而且与阿尔茨海默病、动脉粥样硬化、癌症等常见人类疾病相关。Recently, many researches have indicated that cells possess their ability to regulate a number of genes in response to hypoxia. As a result, alternative splicing of many expressed genes is altered, which plays an important role in hypoxia response. Moreover, hypoxia response signaling pathways mediated by hypoxia inducible factors are essential in the progress of body adaption to hy- poxia condition, thereby regulating erythropoietin, revascularization, glycolysis, and other proces- ses. On the other hand, many alternative splicing factors and proteins, including hypoxia inducible factor, inhibitory PAS protein, prolyl hydroxylase, vascular endothelial growth factor, aryl hydrocar- bon receptor nuclear translocator, are also subject to other regulatory pathways. Alternative splicing not only plays important roles in hypoxia, but also relates to many common human diseases, such as Alzheimer disease, atherosclerosis, and cancer.

关 键 词：选择性剪接 低氧应答 低氧诱导因子 

分 类 号：Q513[生物学—生物化学] Q522.2