生物合成聚羟基烷基酸酯的研究与开发进展  

Progress in the Research and Development of Biosynthesis of Polyhydroxyalkanoates

作　　者：杨丹[1] 刘宏超[1] 黄慧珍[1] 

机构地区：[1]广东海洋大学理学院,湛江524088

出　　处：《高分子通报》2009年第5期42-47,共6页Polymer Bulletin

基　　金：广东省自然科学基金项目(033984)资助

摘　　要：聚羟基烷基酸酯(PHA)是近20年来迅速发展起来的一种生物高分子材料,是一种具有高分子的基本性质的可热塑加工成型的聚酯。PHA最突出性能是具有优良的生物相容性和可生物降解性,因此在医学、药物、工业、农业等领域具有其独特的应用。本文综述了PHA的研究开发历史、国外发展概况、我国目前研究开发现状和国内外生物合成聚羟基烷基酸酯的研究与开发的一些最新研究成果,着重介绍了发掘具有高合成效率的新菌种、利用基因工程技术获取重组菌株、使用低成本碳源、开发合适的提取工艺等方面的工作。Polyhydroxyalkanoates （PHA） is a biopolymer materials developed rapidly in the last 20 years. It is a polymer with the basic polymer properties and could be thermoplastic molding processed. The most prominent properties of PHA are their good biocompatibility and biodegradability. Therefore PHA has unique applications in the medical, pharmaceutical, industrial, agricultural, and other fields. This paper reviews the history of the research and development of PHA, the current overseas and domestic research and development status, and some the latest research results of PHA. The paper also emphatically introduces the research work on the PHA about disinterring new bacteria species with high synthetic efficiency, using gene engineering technology to obtain recombinant strains, using low-cost carbon source and developing the suitable extraction process.

关 键 词：聚羟基烷基酸酯(PHA) 生物合成 生物高分子 

分 类 号：TQ316.3[化学工程—高聚物工业]