丹参复方液对大鼠肥大心肌L型钙电流的影响  

Effect of salvia miltiorrhiza compound liquid on L-type calcium channels in rats with cardiac hypertrophy

作　　者：王佐妤[1] 韩晨光[2] 赵娟[1] 李海英[1] 佟长青[1] 

机构地区：[1]武警医学院生理学与病理生理学教研室 [2]武警医学院附属医院医教部,天津300162

出　　处：《武警医学院学报》2009年第10期849-852,共4页Acta Academiae Medicinae CPAPF

基　　金：武警医学院院级课题资助项目(WY2005-5)

摘　　要：【目的】探讨丹参复方液对高血压性肥大心肌L型钙电流的影响。【方法】利用腹主动脉缩窄法建立高血压性心肌肥大模型,利用灌胃法给予丹参复方液,采用离体大鼠心脏Langendorff灌注法急性分离心肌细胞,利用膜片钳全细胞技术记录L型钙电流,比较正常对照组、高血压未治疗组和丹参复方液组之间的区别。【结果】高血压未治疗组的L型钙电流密度显著高于正常对照组(P<0.05),丹参复方液组显著小于高血压未治疗组(P<0.05),丹参复方液组与正常对照组相比无显著性差异(P>0.05)。【结论】丹参复方液具有逆转高血压性肥大心肌L型钙电流的药理作用。[Objective] To observe the effect of Salvia mihiorrhiza SM compound liquid on cardiocyte L-type calcium channel of cardiac hypertrophy induced by hypertension. [Methods] Cardiac hypertrophy models were made by partial ligation abdominal aortic. SM compound liquid was given by intragastric administration. Langendorff system was used to dissociate single ventricular cell. The current of L-type calcium channels was recorded by whole-cell patch clamp recording technique and compared with control group, hypertension without therapy group and SM compound liquid group. [Resuits] The current density of L-type calcium channels of hypertension without therapy group was higher than that of control group significantly（ P 〈 0.05）. The current density of L-type calcium channels of SM compound hquid group was lower than that of hypertension without therapy group significantly （ P 〈 0.05） . There was no significant difference between control group and SM compound liquid group （P 〉 0.05） . [Conclusions] SM compound liquid can reverse cardiocyte L type calcium channel of cardiac hypertrophy induced by hypertension.

关 键 词：丹参复方液 高血压病 心肌肥大 L型钙电流 

分 类 号：R424[医药卫生—临床医学]