维生素D与自身免疫性甲状腺疾病  

Vitamin D and autoimmune thyroid disease

作　　者：韩钧凌[1] 孙嘉[2] 

机构地区：[1]中国人民解放军第一八七医院内分泌科,海口571159 [2]南方医科大学珠江医院内分泌科,广州510282

出　　处：《国际内分泌代谢杂志》2009年第4期260-263,共4页International Journal of Endocrinology and Metabolism

基　　金：海南省卫生厅科研立项课题（琼卫2008-79）

摘　　要：近年来较多的研究表明，维生素D具有调节免疫的特性，在一些自身免疫性疾病动物模型中表现出一定的防治作用。自身免疫性甲状腺疾病（AITD）是一种器官特异性自身免疫性疾病。研究证实，维生素D相关基因多态性与AITD相关，如维生素D受体基因、1α-羟化酶（CYP2781）基因、维生素D结合蛋白基因等。AITD患者存在维生素D缺乏，一些研究表明应用维生素D对AITD具有一定的防治作用。维生素D及其类似物防治AITD的可能机制在于它们能够调节AITD患者的细胞因子表达，并对其甲状腺细胞凋亡具有调节作用。因此认为，维生素D及其类似物在AITD的临床应用前景广阔。In recent years,the role of vitamin D in the immune system has been investigated. The immunomodulatory properties of vitamin D compounds were illustrated by their ability to either prevent or suppress animal models of autoimmune disease. Autoimmune thyroid diseases （AITD） are organ-specific autoimmune diseases. It was testified that AITD were associated with the polymorphisms of vitamin D related genes,such as vitamin D receptor gene,25-hydroxyvitamin D3-1α-hydroxylase （ CYP27B1 ） gene, vitamin D- binding protein gene, etc. Patients with AITD were coexisted with vitamin D deficiency and vitamin D supplementation benefited for the prevention and treatment of AITD. The probable mechanisms of vitamin D and its analogs in AITD maybe include modulating the expression of many cytokines in AITD and regulating apoptosis of thyroid cells. Thus we postulate that vitamin D and its analogs have a broad prospect in the clinical application for AITD.

关 键 词：维生素D 自身免疫性甲状腺疾病 GRAVES病 桥本甲状腺炎 

分 类 号：R581[医药卫生—内分泌] R681[医药卫生—内科学]