中枢食欲调节研究进展  

Recent progress of appetite regulation in central nervous system

作　　者：程笑冰[1] 宁光[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢病科、上海市内分泌代谢病研究所、上海市内分泌代谢病临床医学中心,200025

出　　处：《国际内分泌代谢杂志》2009年第4期281-284,共4页International Journal of Endocrinology and Metabolism

摘　　要：食欲调节网络的协调性摄食活动是维持人类生命的基本生理活动，食欲调节具有复杂而精细的调节机制，而下丘脑正是接受、整合与发放食欲调节信号、维持体重稳定的重要中枢。中枢神经系统或外周组织产生的具有促／抑食欲作用的神经内分泌因子在下丘脑形成复杂的食欲调节网络和相互投射的神经环路，对食欲进行精确的调控。不断完善下丘脑食欲调节区域，不断发现新的调控因子及其作用机制，对深入了解肥胖及糖尿病的病理生理机制及设计开发各种有效控制体重和血糖的药物有重大意义。Concordant ingestion of appetite regulation internet is the basic physiological activity of human. Appetite regulation relates to complicate mechanisms and involves many systems and factors. Their impacting and controlling formed the appetite regulation internet. The hypothalamus plays a crucial role in recepting,integrating and releasing signals of energy status in central nervous system. The consummated construction of hypothalamus about appetite regulation and the finding of new regulation factors are very important for the learning of mechanism of obesity and diabetes and the development of drugs.

关 键 词：食欲调节 下丘脑 食欲调节因子 神经肽 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]