银丹心脑通软胶囊对垂体后叶素致心肌缺血大鼠心电图的影响  

Effect of Yindanxinnaotong Capsule on the Electrocardiogram in Rats with Acute Myocardium Ischemia Induced by Pituitary

作　　者：王钰莹[1,2] 魏英[1] 夏文 安斯扬 李星 余丽梅[1] 何娜[1] 孙安盛[1] 

机构地区：[1]贵州省基础药理重点实验室 [2]遵义医学院 [3]贵州百灵企业集团制药股份有限公司

出　　处：《中西医结合心脑血管病杂志》2009年第7期804-805,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：贵州省科技厅基金资助项目(黔科合中药专字[2007]5017号)

摘　　要：目的观察银丹心脑通软胶囊对垂体后叶素(pituitrin,Pit)致心肌缺血大鼠心电图的影响。方法采用大鼠舌下静脉注射Pit造成急性心肌缺血模型,观察各给药组在注射Pit后不同时间点Ⅱ导联心电图T波变化百分率和心率的变化。结果银丹心脑通软胶囊低、高剂量组与模型组比较,均能明显降低心肌缺血大鼠心电图T波峰值变化百分率(P<0.05),与注射Pit前比较,能对抗Pit致心率减慢的损伤(P<0.05)。结论银丹心脑通软胶囊具有抗Pit引起的大鼠急性心肌缺血的作用。Objective To observe the effect of Yindanxinnaotong capsule on the electrocardiogram（ ECG） in rats with acute myocardial ischemia induced by pituitary. Methods Acute myocardium ischemia rat models were established by suhlingual venous injec lion of pituitrin. The changes of the T wave in lead Ⅱ ECG and heart rate were observed. Results Yindanxinnaotong capsule could simificantly lower the percentage change of T wave and inhibit slowed heart rate induced by pituitrin in rats. Conclusion Yindanxinnaotong capsule had anti - myocardial ischemia effets on rats with acute myocardiurn ischemia induced by pituitary.

关 键 词：银丹心脑通软胶囊 垂体后叶素 心肌缺血 心电图 

分 类 号：R285.5[医药卫生—中药学]