N-乙酰-L-半胱氨酸在多壁碳纳米管修饰玻碳电极上的电催化氧化及电分析方法  

Electrocatalytic oxidation and its Electroanalytical method of N-Acetyl-L-Cysteine at multi-wall carbon nanotubes modified glassy carbon electrode

作　　者：任超超[1] 高作宁[1] 

机构地区：[1]宁夏大学能源化工重点实验室,化学化工学院,银川750021

出　　处：《药物分析杂志》2009年第7期1183-1186,共4页Chinese Journal of Pharmaceutical Analysis

基　　金：宁夏高等学校科学研究基金(200623)项目资助

摘　　要：目的:研究了N-乙酰-L-半胱氨酸(N-Acetyl-L-Cysteine,NAC)在多壁碳纳米管修饰玻碳电极(MWCNT/GCE)上的电化学行为及电分析方法。方法:运用循环伏安法(CV)、计时库仑法(CC)、计时电流法(CA)、线性扫描伏安法(LSV)。结果:NAC在GCE上的直接电化学氧化十分迟缓,无氧化峰出现,而在MWCNT/GCE上于0.15V处出现一个不可逆氧化峰。研究了实验条件对NAC电化学行为的影响。测定了电催化过程动力学参数:扩散系数D为5.26×10-5cm2.s-1,电子转移系数α为0.55,电极反应速率常数kf为7.95×10-3s-1。对含NAC的药物进行电化学定量测定,RSD%在1.2%～2.4%之间,加标回收率在101.6%～102.2%之间。结论:MWCNT/GCE对NAC具有良好的电催化氧化作用,是一受扩散控制的不可逆电催化氧化过程,对NAC样品含量进行电化学定量测定,测定结果令人满意。Objective ： Electrochemical behavior and electroanalysis of N - Acetyl - L - Cysteine （ NAC ） at multi- wall carbon nanotubes modified glassy carbon electrode（MWCNT/GCE）was studied. Methods：Cyclic vohammetry （ CV ） ; Chronocoulometry （ CC ） ; Chronoamperometry （CA） and linear scan voltammetry （ LSV ）. Results： The direct electrochemical oxidation of NAC is sluggish on GCE, no oxidation peaks appeared. However, it appears an irreversible oxidation peak on MWCNT/GCE at 0. 15 V. It has also done the research on the influence of the experimental conditions on NAC electrochemical behaviors. The kinetic parameters of this process were calculated, the diffusion coefficient was 5.26 ×10^-5cm^2·s^-1 ,the electron transfer coefficient was 0. 55, and the electrode reaction rate constant was 7.95×10^-3s^-1. The research results can be applied in determination of the content of commercial NAC pharmaceutical products. The relative standard deviation in 1.2% - 2. 4% , and the recovery is 101.6% - 102.2%. Conclusions：The results indicate that MWCNT/GCE can catalyze the electrochemical oxidation of NAC very well. The electrode process was a diffusion-limited. The proposed method can be applied in the determination of NAC in tablet samples with the satisfied results.

关 键 词：N-乙酰-L-半胱氨酸 碳纳米管修饰电极 电催化氧化 电分析方法 

分 类 号：R917[医药卫生—药物分析学]