壳聚糖-g-水杨酸的药理活性研究  

Pharmacological activity of chitosan-g-salicylic acid derivatives

作　　者：武雪芬[1] 崔晓鸽[1] 李合平[1] 孙德梅[1] 李桂兰[2] 

机构地区：[1]河南中医学院,郑州450008 [2]郑州大学化学系,郑州450052

出　　处：《中国新药杂志》2009年第14期1328-1332,共5页Chinese Journal of New Drugs

基　　金：河南省重点攻关项目(092101310200)

摘　　要：目的:考察不同相对分子质量、不同接枝率壳聚糖-g-水杨酸的药理活性,为发现水杨酸或阿司匹林的替代药物提供基础化合物。方法:以水杨酸和阿司匹林为阳性对照,考察不同相对分子质量、不同接枝率壳聚糖-g-水杨酸的抗炎、镇痛和抗凝血作用,以此评价壳聚糖-g-水杨酸与原药的药理活性差异。结果:在主药阿司匹林浓度相等情况下,壳聚糖-g-水杨酸的抗炎活性和抗凝血活性与阿司匹林相当,即时镇痛作用弱于阿司匹林,长效镇痛作用优于阿司匹林。结论:壳聚糖-g-水杨酸具有与阿司匹林相当的抗炎、镇痛和抗凝血活性,具有较好的开发应用前景。Objective：To investigate pharmacological activity of different molecular weight and different rates of graft chitosan-g-salicylic acid. Methods ： The pharmacological effect of the drug difference, anti-inflammatory, analgesic and anticoagulant function of different molecular weight, different rates of graft chitosan-g-salicylic acid was investigated, with salicylic acid and aspirin as the positive control. The difference of pharmacology was measured between chitosan-g-salicylic acid and positive control. Results：At the same concentration level, the anti-inflammatory activity and the anticoagulant activity of chitosan-g-salicylic was equal to those of aspirin,and the immediate analgesic effect was weaker than that of aspirin. The long-term analgesic effect was better than that of aspirin. Conclusion：Chitosan-g-salicylic acid shows considerable anti-inflammatory, analgesic and anti-clotting activities compared with aspirin, and has the fine application prospect.

关 键 词：壳聚糖-g-水杨酸 抗炎 镇痛 抗凝血 

分 类 号：R971.1[医药卫生—药品]