特异性免疫治疗对慢性鼻窦炎手术预后干预作用研究  

Research On ASIT’s Intervention In CRS After FESS

作　　者：郭杰峰[1] 李小敏[1] 樊韵平[2] 王静清[2] 

机构地区：[1]珠海市人民医院耳鼻咽喉科 [2]中山大学附属第五医院耳鼻咽喉科,珠海519000

出　　处：《中国医疗前沿》2009年第13期2-4,共3页China Healthcare Innovation

基　　金：珠海市卫生局立项课题(项目编号:2008004)

摘　　要：目的探讨特异性免疫治疗(Allergen-specific immunologic therapy:ASIT)对慢性鼻窦炎(chronic rhinosinusitis:CRS)伴常年性变应性鼻炎患者行功能性鼻窦内窥镜手术(functional endoscopic sinus surgery:FESS)预后干预作用。方法采用随机分组方法将确诊慢性鼻窦炎伴常年性变应性鼻炎患者随机分成两组,治疗Ⅰ组:FESS+术后ASIT组;治疗Ⅱ组:FESS组。分别对两组患者进行术前、术后6个月、术后一年症状及体征评分并进行对比,采用鼻腔鼻窦结局测量20条(SNOT-20),鼻内镜(Lund-kennedy)评分法及CT(Lund-mackay)评分法。结果两组患者术后6个月及一年SNOT-20量表的20个条目总分与5大条目总分指标均有明显好转(P<0.05),但两组间存在显著性差异,治疗Ⅰ组疗效优与治疗Ⅱ组。结论特异性免疫治疗可减少慢性鼻窦炎术后复发,改善预后。Objective To investigate ASIT＇s intervention in patients with chronic rhinosinusitis accompanied with perennial rhinitis after FRSS. Methods To divide patients with chronic rhinosinusitis into two groups randomly： Group 1 ：FESS＋ASIT after operation, Group 2：FESS only.To compare the symptom and physical sign of the 2 groups before the operation and 6 and 12 months after the operation,with SNOT-20 and Lund-Kermedy and Lurid-Mackay Standard. Result Both of the 2 groups final score and index of the 20 items of SNOT-20 and the other 5 items were Greatly improved,however there is an obvious difference between them：the therapeutic effect of groups 1 is better than group 2. Conclusions Allergen-Specific Immunologic Therapy can reduce the recurrence of chronic rhinosinusitis after operation, and improve the state after treatment.

关 键 词：免疫治疗 鼻窦炎 内窥镜检查 外科手术 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]