氨酚羟考酮与曲马多治疗肝癌TACE术后栓塞综合征的比较研究  

Comparison of efficacy and safety of oxycodone-acetaminophen versus tramadol in treating post embolization syndrome after transarterial chemoembolization

作　　者：邢文阁[1] 郭志[1] 刘方[1] 于海鹏[1] 李保国[1] 王海涛[1] 邹强[1] 郭秀英[1] 

机构地区：[1]天津医科大学附属肿瘤医院介入治疗科,天津300060

出　　处：《中国新药杂志》2009年第12期1116-1118,1140,共4页Chinese Journal of New Drugs

基　　金：国家十一五科技支撑计划项目(2007BAI05B06)

摘　　要：目的:观察肝癌选择性肝动脉栓塞化疗(Transarterial chemoembolization,TACE)术后口服氨酚羟考酮(泰勒宁)和盐酸曲马多(奇曼丁)进行治疗栓塞后综合征的有效性和安全性。方法:60例NRS评分>3分的肝癌TACE术后男性患者,随机分两组,分别口服泰勒宁和奇曼丁。观察并记录术后即刻、术后0.5,0,1,2,6,12,24,48,72 h的NRS评分、疼痛强度与缓解度变化、EORTC QLQ-C30评分以及不良反应。结果:氨酚羟考酮组、曲马多组均能在术后1 h达到较为满意止痛效果,但氨酚羟考酮组起效时间较曲马多组为短,在术后0.5 h可达到满意效果。与治疗前比较,两组生活质量均有提高。曲马多组发热高于氨酚羟考酮组,两组恶心、呕吐、头晕发生率相仿,但氨酚羟考酮组的消化道反应及嗜睡较曲马多组为多。结论:氨酚羟考酮较曲马多更适于肝癌TACE栓塞后综合征的对症治疗,值得临床推广使用。Objective： To compare the efficacy and safety of oxycodone-acetaminophen versus tramadol in the treatment of post embolization syndrome after transarterial chemoembolization （TACE） in patients with primary hepatic carcinoma. Methods： In 60 male patients with primary hepatic carcinoma, whose numerical rating scales （NRS） 〉 3 after TACE procedure, were randomly divided into two groups. They were treated with either oxycodone-acetaminophen （n = 30） or tramadol （n = 30）. NRS scores, odynolysis, EORTC QLQ-C30 and untoward reactions were observed and recorded 0.5, 1 , 2, 6, 12, 24, 48 and 72 h after the operation. Results： Patients in both groups showed satisfaction effects in 1 h after the operation. The pain-relieving effect of oxycodone-acetaminophen at 0.5 h was better than that of tramadol. The quality of life of patients was higher in oxycodone-acetaminophen group than in tramadol group. However, the digestive tract reactions and drowsiness were more frequent in oxycodone-acetaminophen group. Conclusion： Oxycodone-acetaminophen is more suitable than tramadol for the treatment of HCC paitents with post embolization syndrome after TACE.

关 键 词：肝癌 选择性肝动脉栓塞化疗 氨酚羟考酮 曲马多 栓塞后综合征 

分 类 号：R971.1[医药卫生—药品]