芍药苷微乳体外经皮渗透性的研究  

In vitro permeability of paeoniflorin microemulsion

作　　者：聂欣欣[1] 姜玲[1,2] 魏伟[1] 杨昭毅[1] 王春[1] 

机构地区：[1]安徽医科大学临床药理研究所,抗炎免疫药理学安徽省重点实验室,抗炎免疫药物安徽省工程技术研究中心,安徽省中药研究与开发重点实验室,合肥230032 [2]安徽省立医院,合肥230001

出　　处：《中国新药杂志》2009年第12期1155-1158,共4页Chinese Journal of New Drugs

基　　金：高校博士点科研基金(20060366003);安徽省研究实验基地优秀中青年科研带头人基金(200622805);安徽医科大学校科研基金(2006kj21)

摘　　要：目的:研究芍药苷微乳对离体小鼠皮肤的渗透能力。方法:采用Franz扩散池,以雄性小鼠腹皮为渗透屏障,高效液相色谱法测定药物累积渗透浓度,并计算累积渗透量(Q)和渗透速率(J)。结果:芍药苷微乳24 h内的透皮吸收量明显高于其原料药,微乳中芍药苷的渗透过程符合H iguchi模型。结论:芍药苷微乳透皮吸收效果良好,具有开发成为外用制剂的潜力。Objective： To study the in vitro permeability of the paeoniflorin microemulsion. Methods： Franz diffusion cells were used for the permeation study. The concentration of paeoniflorin across the male mouse skin was measured by HPLC. The accumulative amount of the permeated paeoniflorin （Q） and permeation rate （J） were calculated. Paeoniflorin was used as control. Results： The accumulative amount of the permeated paeoniflorin in the microemulsion vehicle was much higher than of the drug alone in 24 h. The permeation process of the paeoniflorin microemulsion across the mouse skin fitted Higuchi equation. Conclusion： The paeoniflorin microemulsion shows an improved in vitro permeability, suggesting it may be a potent transdermal formulation of paeoniflorin.

关 键 词：芍药苷 微乳 透皮给药 

分 类 号：R943.43[医药卫生—药剂学]