格拉司琼治疗呃逆101例  

Analysis of 101 cases for the treatment of hiccup with granisetron

作　　者：张俊凯[1] 康国强[1] 白秀丽[1] 高福兰[1] 

机构地区：[1]河北省黄骅市人民医院内一科,黄骅061100

出　　处：《中国新药杂志》2009年第13期1211-1212,1236,共3页Chinese Journal of New Drugs

摘　　要：目的:观察格拉司琼对呃逆的疗效。方法:207例呃逆患者分为2组,试验组101例,其中顽固性呃逆22例,采用格拉司琼治疗,3 mg静脉点滴,qd,疗程5 d。对照组106例,其中顽固性呃逆20例,肌内注射胃复安10 mg,bid,及针灸等常规方法治疗。结果:试验组总有效率93.1%,对照组总有效率79.3%(P<0.01),试验组的治愈率75.3%,对照组的治愈率45.3%(P<0.01)。试验组用药1 d起效率79.2%,对照组用药1 d起效率37.7%(P<0.01)。试验组无不良反应.对照组2例出现锥体外系症状。结论:格拉司琼治疗呃逆安全有效。Objective：To evaluate the therapeutic effect of granisetron on hiccup. Methods：A total 207 patients with hiccup were divided into two groups. They were treated either with intravenous drop of 3 mg granisetron for 5 days （n = 101 , 69 males and 32 females, including 22 patients with intractable hiccup） , or with intramuscular injection of 10 mg metoclopramide, bid, combined with acupuncture and other treatments （control, n = 105, 65 males and 41 females, including 20 patients with intractable hiccup）. Results： Total effective rates were 93. 1% and 79. 3% , respectively, and the healing rates were 75.3% and 45.3 % , respectively, in granisetron and control groups （P 〈0.01 ）. The effective rates within 1 day were 79.2% and 37.7% , respectively, in granisetron and control groups （ P 〈 0.01 ）. No adverse reactions were found in granisetron group; extrapyramidal symptoms were found in 2 patients of control group. Conclusion ： Granisetron is effective and safe in the treatment of hiccup.

关 键 词：呃逆 治疗方法 格拉司琼 

分 类 号：R975[医药卫生—药品]