硫酸沙丁胺醇药物树脂的制备及其影响因素考察  

Preparation and influence factors of salbutamol sulfate resin

作　　者：张萱怡[1] 张向荣[1] 吕娟丽[2] 雷杨[1] 刘薇[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院,沈阳110016 [2]武警总医院药剂科,北京100039

出　　处：《中国新药杂志》2009年第13期1262-1265,共4页Chinese Journal of New Drugs

摘　　要：目的：制备硫酸沙丁胺醇药物树脂，并对影响因素（粒径、浓度、温度、交联度、流速）进行考察。方法：静态载药法和动态载药法。结果：静态载药的优化条件是温度为25℃，药物浓度为6mg·mL^-1，树脂粒径为180～240目；动态载药的优化条件是温度为30℃，药物浓度为8mg·mL^-1，树脂粒径为180～240目，流速1mL·min。结论：采用静态载药法制备硫酸沙丁胺醇药物树脂。Ojective：To prepare salbutamol sulfate resins and evaluate the factors that affect the preparation. Methods：Bath method and column method were utilized. Results：The preparation of salbutamol sulfate resins using the bath method was optimized with drug concentration of 6 mg·mL-1 and resin particle size of 180 - 240 mesh at 25℃. The optimal conditions of the column technique were drug concentration of 8 mg·mL^-1 and resin particle size of 180 - 240 mesh at 25 ℃ , and the efflux speed at 1 mL·min^-1. Conclusion ： Salbutamol sulfate resins could be prepared by bath method.

关 键 词：硫酸沙丁胺醇 离子交换树脂 静态交换载药法 动态交换载药法 

分 类 号：R943.41[医药卫生—药剂学] R974.3[医药卫生—药学]