肉桂油对小鼠胃白念珠菌感染的治疗作用  

Therapeutic effect of cinnamon oil on gastric candida albicans infection in mice

作　　者：马耀辉[1] 邓洁华[1] 王刚生[1] 张晓光[1] 王爱学[1] 四荣联[1] 

机构地区：[1]河北医科大学第二医院,河北省石家庄市050000

出　　处：《世界华人消化杂志》2009年第15期1545-1547,共3页World Chinese Journal of Digestology

摘　　要：目的:探讨肉桂油治疗胃白念珠菌感染的可行性.方法:制作胃白念珠菌感染小鼠120只,随机分为4组,每组30只.肉桂油治疗组分3组,每天给予1mL1.25、1.88、2.5g/L肉桂油溶液灌胃,对照组每天给予50g/L葡萄糖溶液1mL灌胃,10d后取小鼠胃组织行真菌镜检及组织病理检查,发现白念珠菌菌丝为阳性.结果:3个浓度的肉桂油治疗组的真菌镜检及组织病理检查阳性率均显著低于对照组(χ2=14.14,6.97,7.04;30.08,25.36,28.09,均P<0.01),肉桂油治疗组之间比较无差异(χ2=2.04,0.28,P>0.05).结论:三种浓度肉桂油均可杀死小鼠胃内的白念珠菌,肉桂油可用来治疗胃白念珠菌感染.AIM： To investigate feasibility of treating gastric candida albicans infection with cinnamon oil. METHODS： One hundred and twenty mouse models of candida albicans infection were established and randomly divided into four groups （n = 30）. Three cinnamon oil treatment groups were given 1.25 g/L, 1.88 g/L, 2.5 g/L cinnamon oil solution I mL by gastric intubation daily, while the control group was given 50 g/L glucose solution 1 mL by gastric intubation daily. Ten days later, fungal microscopy and histopathological examination were performed on stomach tissue of mice. RESULTS： Positive rates of fungal microscopy and histopathological examination in cinnamon oil treatment groups were significantly lower than control group （2 = 14.14, 6.97, 7.04; 30.08, 25.36, 28.09, all P 〈 0.01）. No significant differ-ence was observed among three cinnamon oil treatment groups （2 =2.04, 0.28, P 〉 0.05）. CONCLUSION： Three concentrations of cinnamon oil can kill gastric candida albicans and cinnamon oil can be used for the treatment of gastric candida albicans infection.

关 键 词：肉桂油 小鼠 胃 白念珠菌 

分 类 号：R285.5[医药卫生—中药学]