利咽泡腾颗粒小鼠急性毒性试验  

Acute toxicity experiment of Liyan effervescent granules in mice

作　　者：谭家风[1] 徐进[1] 黄薇薇[1] 

机构地区：[1]南京医科大学附属南京儿童医院药剂科,江苏210008

出　　处：《交通医学》2009年第2期135-136,共2页Medical Journal of Communications

基　　金：南京市科技发展计划项目(200601054)

摘　　要：目的:观察利咽泡腾颗粒一次灌胃后小鼠的急性毒性反应及其安全性。方法:将利咽泡腾颗粒的原料利咽清膏以最大浓度、最大体积给予小鼠灌胃,测其最大耐受量。结果:小鼠利咽泡腾颗粒灌胃给药的LD50无法测出,最大耐受量为111.6g/kg(生药),相当于成人临床日用量的200倍,未出现任何毒性表现。结论:利咽泡腾颗粒毒性很小,临床用药安全。Objective： To study the acute toxicity and safety of Liyan effervescent granules after intragastric administration at a single maximum concentration dose in mice. Methods： The half-lethal dose was unavailable after single intragastric administration.The maximally tolerated dose was measured after intragastric administration at a maximal concentration and volume of Liyan plaster （raw materials of Liyan effervescent granules）. Results： The maximally tolerated dose to Liyan effervescent granules was 111.6g/kg（equivalently to crude drug）, equally to 200 times of adult＇s dosage. Conclusion： Liyan effervescent granules has very low toxicity but wide safety range in clinical application.

关 键 词：利咽泡腾颗粒 急性毒性 灌胃给药 小鼠 

分 类 号：R99[医药卫生—毒理学]