药物阿司匹林剂型的研究进展  

Advances in Aspirin Dosage Form

作　　者：张培培[1] 唐忠锋[2,3] 

机构地区：[1]扬州工业职业技术学院应用化学系,江苏扬州225127 [2]广西工学院生物与化学工程系,广西柳州545006 [3]柳州市欧博科技有限公司,广西柳州545006

出　　处：《中国现代应用药学》2009年第7期542-545,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：柳州市高新开发区资助项目(2007010109)

摘　　要：目的为提高阿司匹林的药效且减少其对胃肠道的不良反应,从而为阿司匹林新剂型的研发提供方向。方法通过分析与归纳文献内容等方法对阿司匹林不同剂型的研究意义、方法及结果等进行了论述。结果提出了当前的肠溶剂、缓释或控释剂、复方制剂、泡腾片等剂型的研究现状和存在的问题,指明了阿司匹林剂型的研究趋势和发展方向。结论缓释控释剂型将是阿司匹林剂型的发展方向。选择合适的辅料,简化制备工艺,降低成本,提高药效将是未来研究的重点。OBJECTIVE To enhance the effect of aspirin and reduce its side effects on gastrointestinal tract, this paper guides the research of new dosage forms of aspirin. METHODS The significance, methods and results of different dosage forms are summarized by generalizing and contrasting. RESULTS The new dose forms include enteric coated aspirin, con-trolled-release and prolonged-release aspirin, compound aspirin, effervescent tablets, et al. Based on the analysis of the recent developments and problems, the prospects of the new dose forms are put forward. CONCLUSION Controlled-release and pro-longed-release aspirin is the trend of research, and the key is to choose suitable minor ingredients, simplify preparation technolo-gies, lower the cost and enhance the effect.

关 键 词：阿司匹林 剂型 肠溶剂 复方制剂 缓释控释制剂 

分 类 号：R971.1[医药卫生—药品]