外周N-甲基-D-天门冬氨酸受体在福尔马林外周注射引起长时程痛敏中的作用  

Peripheral N-methyl-D-aspartate Receptors Involved in Long-term Hyperalgesia Induced by Peripheral Injection of Formalin in Rats

作　　者：程涓[1] 张策[2] 

机构地区：[1]北京中医药大学东直门医院病理科,北京市100700 [2]山西医科大学生理学教研室,山西太原市030001

出　　处：《中国康复理论与实践》2009年第7期625-627,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的观察外周N-甲基-D-天门冬氨酸(NMDA)受体对福尔马林外周注射所致长时程痛敏的作用。方法雄性SD大鼠脚掌注射福尔马林,之前注射或不注射MK-801。免疫组化方法检测脊髓背角小胶质细胞OX-42表达,测定热辐射痛行为。结果注射MK-801侧脊髓背角Ⅰ、Ⅱ层小胶质细胞OX-42阳性表达水平较对侧(仅注入福尔马林侧)明显降低。单独注入福尔马林后第3天发生热痛敏,第7天达高峰,第10天仍未完全恢复至正常值;外周应用MK-801后,热痛敏反射潜伏期延长。结论NM-DA受体参与长时程痛敏的产生和维持。Objective To investigate the role of peripheral N-methyl-D-aspartate （NMDA） receptors in the tong-term hyperalgesia induced by peripheral injection of formalin in rats. Methods Formalin was injected in the paws of the SD rats with or without the MK-801 pre-injection. OX-42 expressions in the dorsal horn were observed, and the paw withdrawal thermal latency was measured. Results The OX-42 expression decreased and the paw withdrawal thermal latency prolonged in rats with MK-801 pre-injection. Conclusion Peripheral NMDA receptors may be involved in the long term hyperalgesia.

关 键 词：长时程痛敏 福尔马林实验 小胶质细胞 N-甲基-D-天门冬氨酸(NMDA)受体 MK-801 OX-42 大鼠 

分 类 号：R441.1[医药卫生—诊断学]