Virion Proteomics of Large DNA Viruses  

作　　者：Ran-ran WANG Zhi-hong HU Hua-lin WANG Fei DENG 

机构地区：[1]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071,China

出　　处：《Virologica Sinica》2009年第4期268-284,共17页中国病毒学（英文版）

基　　金：The grants of National Science Foundation of China (30630002, 30670078);973 Program(2009CB118903);Programme Strategic Scientific Alliances between China and the Netherlands (2008AA000238)

摘　　要：Large DNA viruses normally have complex structures with many of protein components derived from both viral and host origins. The development in proteomics, especially mass spectrometry identification techniques provide powerful tools for analyzing large viruses. In this review, we have summarized the recent achievements on proteomic studies of large DNA viruses, such as herpesvirus, poxvirus, nimavirus and baculoviruse. The proteomics of baculovirus occlusion-derived virions (ODV) were emphasized. Different mass spectrometry techniques used on various baculoviruses were introduced, and the identified structurally associated proteins of baculoviruses are summarized.Large DNA viruses normally have complex structures with many of protein components derived from both viral and host origins. The development in proteomics, especially mass spectrometry identification techniques provide powerful tools for analyzing large viruses. In this review, we have summarized the recent achievements on proteomic studies of large DNA viruses, such as herpesvirus, poxvirus, nimavirus and baculoviruse. The proteomics of baculovirus occlusion-derived virions （ODV） were emphasized. Different mass spectrometry techniques used on various baculoviruses were introduced, and the identified structurally associated proteins ofbaculoviruses are summarized.

关 键 词：Virion proteomics Large DNA viruses BACULOVIRUSES 

分 类 号：S858.23[农业科学—临床兽医学] Q51[农业科学—兽医学]